Arrestins - Pharmacology and Therapeutic Potential

Front Matter....Pages i-viii
Therapeutic Potential of Small Molecules and Engineered Proteins....Pages 1-12
Front Matter....Pages 13-13
Arrestin Interactions with G Protein-Coupled Receptors....Pages 15-56
Quantifying Biased β-Arrestin Signaling....Pages 57-83
The Physiological Roles of Arrestin-1 in Rod Photoreceptor Cells....Pages 85-99
Not Just Signal Shutoff: The Protective Role of Arrestin-1 in Rod Cells....Pages 101-116
Cone Arrestin: Deciphering the Structure and Functions of Arrestin 4 in Vision....Pages 117-131
Enhanced Phosphorylation-Independent Arrestins and Gene Therapy....Pages 133-152
Targeting Individual GPCRs with Redesigned Nonvisual Arrestins....Pages 153-170
Front Matter....Pages 171-171
β-Arrestins and G Protein-Coupled Receptor Trafficking....Pages 173-186
Arrestin Interaction with E3 Ubiquitin Ligases and Deubiquitinases: Functional and Therapeutic Implications....Pages 187-203
Self-Association of Arrestin Family Members....Pages 205-223
Arrestin-Dependent Activation of ERK and Src Family Kinases....Pages 225-257
Arrestin-Dependent Activation of JNK Family Kinases....Pages 259-280
Arrestin-Mediated Activation of p38 MAPK: Molecular Mechanisms and Behavioral Consequences....Pages 281-292
Arrestin-Dependent Localization of Phosphodiesterases....Pages 293-307
Arrestins in Apoptosis....Pages 309-339
Molecular Mechanisms Underlying Beta-Arrestin-Dependent Chemotaxis and Actin-Cytoskeletal Reorganization....Pages 341-359
Arrestins in Host–Pathogen Interactions....Pages 361-374
Arrestin Regulation of Small GTPases....Pages 375-385
GPCRs and Arrestins in Airways: Implications for Asthma....Pages 387-403
Front Matter....Pages 171-171
Arrestins as Regulatory Hubs in Cancer Signalling Pathways....Pages 405-425
β-Arrestins: Regulatory Role and Therapeutic Potential in Opioid and Cannabinoid Receptor-Mediated Analgesia....Pages 427-443
Back Matter....Pages 445-447