Apoptosis and Cancer Chemotherapy

Front Matter....Pages i-xv
Does Apoptosis Contribute to Tumor Cell Sensitivity to Anticancer Agents?....Pages 1-19
p53, Apoptosis, and Chemosensitivity....Pages 21-36
The Role of p53 in Chemosensitivity....Pages 37-52
Function of the p53 Gene Family....Pages 53-68
Mismatch Repair Deficiency, Apoptosis, and Drug Resistance....Pages 69-85
Involvement of c-Abl Tyrosine Kinase in Apoptotic Response to Anticancer Agents....Pages 87-98
Bcl-2 Family Proteins....Pages 99-116
Bax, a Death Effector Molecule....Pages 117-128
Bax, a Proapoptotic Protein Forming Channels in Mitochondria....Pages 129-141
Mechanism of Action of the Proapoptotic Gene Bak ....Pages 143-156
Killers or Clean-Up Crew....Pages 157-174
Role of CD95 (APO-1/Fas) System in Chemotherapy....Pages 175-187
Insulin-Like Growth Factor-1 Receptor as a Target for Anticancer Therapy....Pages 189-203
Drug Resistance and the Survival Niche....Pages 205-221
Chemotherapy, Tumor Microenvironment, and Apoptosis....Pages 223-240
Molecular Regulation and Therapeutic Implications of Cell Death in Prostate Cancer....Pages 241-255
Chemotherapy and Apoptosis in the Ovary....Pages 257-273
Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas....Pages 275-290
Apoptosis and Breast Cancer....Pages 291-303
Role of Apoptosis in Human Neuroblastomas....Pages 305-318
Response of Testicular Tumors to Chemotherapy....Pages 319-329
Concluding Remarks....Pages 331-332
Back Matter....Pages 333-342