Antiviral Drug Development: A Multidisciplinary Approach

Front Matter....Pages i-viii
Antiviral Chemotherapy: An Introduction and Reasons for the Slow Progress, Particularly towards Rational Design....Pages 1-9
Design of Nucleoside Analogs as Potential Antiviral Agents....Pages 11-36
Design of Anti-Viral Agents Other than Nucleoside Analogues....Pages 37-54
Antivirals for High Hazard Viruses....Pages 55-72
Human Retroviruses and Anti-Viral Therapies....Pages 73-80
Epstein-Barr Virus....Pages 81-96
Molecular Targets for Selective Antiviral Chemotherapy....Pages 97-122
Inhibition of S-Adenosylmethionine-Dependent Transmethylation as an Approach to the Development of Antiviral Agents....Pages 123-138
Assay Systems: Testing of Antiviral Drugs in Cell Culture (In Vitro)....Pages 139-148
Animal Models as Assay Systems for the Development of Antivirals....Pages 149-172
Experimental Aspects of Antiviral Pharmacology....Pages 173-202
Virus Drug Resistance....Pages 203-236
Interferon as an Antiviral Agent....Pages 237-249
Risk-Benefit Analysis in Drug Research....Pages 251-259
Safety Assessment of Antiviral Drugs....Pages 261-273
Antiviral Agents: A New Beginning....Pages 275-298
Back Matter....Pages 299-309