Antithrombotics: Pathophysiological Rationale for Pharmacological Interventions

Front Matter....Pages i-x
Platelet Activation and Aggregation : Rationale for Combining Antithrombotic Drugs....Pages 1-26
Role of Nitric Oxide in Endothelial Cell - Platelet Interactions....Pages 27-48
Platelets and Megakaryocytes in Vascular Disease....Pages 49-62
Thrombosis in Relation to Atherosclerosis....Pages 63-81
Pharmacological Inhibition of the ADP-GP IIb/IIIa-Fibrinogen Pathway of Platelet Aggregation....Pages 83-97
Calcium Fluxes in Platelets and Endothelial Cells; Mechanisms and Functional Significance....Pages 99-119
Inhibition of Platelet Function by Cyclic Nucleotides and Cyclic Nucleotide-Dependent Protein Kinases....Pages 121-138
Pharmacological Modification of Platelet-Derived Cyclooxygenase Product Formation and Its Consequences for Platelet-Vessel Wall Interactions....Pages 139-158
Antithrombotics and the Lipoxygenase Pathway....Pages 159-179
Pathological Expressions of Platelet-Vessel Wall Interactions: Implications of Serotonin....Pages 181-194
The Involvement of Paf in Thrombotic Events....Pages 195-203
Prostaglandins and -Analogs in The Treatment of Platelet Vessel Wall Interaction....Pages 205-220
Adjuvant Agents to Enhance and Sustain Reperfusion with t-PA: Studies in Experimental Dog Models....Pages 221-232
Effect of Dietary Marine Lipids on (Anti-)Thrombotic Mechanisms....Pages 233-249
Back Matter....Pages 251-261