Antioxidants in Therapy and Preventive Medicine

Front Matter....Pages i-xiii
Extracellular-Superoxide Dismutase, Distribution in the Body and Therapeutic Applications....Pages 1-4
Targeting Sod by Gene and Protein Engineering and Inhibition of Oxidative Stress in Various Diseases....Pages 5-12
The Role of Superoxide Dismutase (SOD) in Preventing Postischemic Spinal Cord Injury....Pages 13-16
Sod in Rat Models of Shock and Organ Failure....Pages 17-27
The Protective Role of Superoxide Dismutase During Activation of Ribonucleotide Reductase....Pages 29-35
Effect of Superoxide Dismutase on the Autoxidation of Hydroquinones Formed During DT-Diaphorase Catalysis and Glutathione Nucleophilic Addition....Pages 37-44
Superoxide Scavengers and SOD or SOD Mimics....Pages 45-50
Reactivity of Active Centre Analogues of Cu 2 Zn 2 Superoxide Dismutase....Pages 51-57
SOD Mimicking Properties of Copper (II) Complexes: Health Side Effects....Pages 59-68
Radiation Recovery Agents: Cu(II), Mn(II), Zn(II), OR Fe(III) 3,5-Diisopropylsalicylate Complexes Facilitate Recovery from Ionizing Radiation Induced Radical Mediated Tissue Damage....Pages 69-77
Effects of Glycyl-Histidyl-Lysyl Chelated Cu(II) on Ferritin Dependent Lipid Peroxidation....Pages 79-84
SOD-Like Activity of 5-Membered Ring Nitroxide Spin Labels....Pages 85-92
Vitamin E in Biological Systems....Pages 93-103
The Role of Vitamin E in the Hepatotoxicity by Glutathione Depleting Agents....Pages 105-110
Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase....Pages 111-116
Quenching of Singlet Molecular Oxygen by Tocopherols....Pages 117-124
Antioxidant Properties of Vitamin E and Membrane Permeability in Human Fibroblast Cultures....Pages 125-128
Vitamin E and Tumor Growth....Pages 129-132
Abnormal Susceptibility to Lipid Peroxidation of Plasma LDL and Its Prevention by α-Tocopherol During Experimental Cholestasis in the Rat....Pages 133-137
The Role of Oxidative Modification and Antioxidants in LDL Metabolism and Atherosclerosis....Pages 139-142
Effects of Vitamin E Treatment in Cholestatic Children....Pages 143-146
Efficacy of Vitamin E as a Drug in Inflammatory Joint Diseases....Pages 147-150
Vitamin E and Correlated Antioxidants: A γ Radiolysis Study....Pages 151-154
Ascorbate: The Most Effective Antioxidant in Human Blood Plasma....Pages 155-163
Radical Chemistry of Flavonoid Antioxidants....Pages 165-170
Scavenging Effects of Aspalathus Linealis (Rooibos Tea) on Active Oxygen Species....Pages 171-174
Selenium and Oxidant Injury in Patients with Cystic Fibrosis....Pages 175-178
Selenium and Glutathione Peroxidase Activity in Diploid Human Fibroblasts: Their Effects Against H 2 O 2 or UV B Induced Toxicity....Pages 179-182
Selenium Therapy in Down Syndrome (DS): A Theory and a Clinical Trial....Pages 183-186
Protection by Seleno-Organic Compound, Ebselen, Against Acute Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats....Pages 187-191
Biological Activities and Clinical Potential of Ebselen....Pages 193-197
Glutathione Level in Mice Brain After Testosterone Administration....Pages 199-202
Prostaglandins, Glutathione Metabolism, and Lipid Peroxidation in Relation to Inflammation in Bovine Mastitis....Pages 203-207
Sulfur Containing Compounds as Antioxidants....Pages 209-215
Zinc — a Redox-Inactive Metal Provides a Novel Approach for Protection Against Metal-Mediated Free Radical Induced Injury: Study of Paraquat Toxicity in E. Coli ....Pages 217-222
Antioxidative Action of Zinc-Carnosine Compound Z-103....Pages 223-228
High Molecular Weight Forms of Deferoxamine: Novel Therapeutic Agents for Treatment of Iron-Mediated Tissue Injury....Pages 229-234
Oxygen Toxicity: Role of Hydrogen Peroxide and Iron....Pages 235-246
Antioxidant Properties of an Antiischaemic Agent : Trimetazidine....Pages 247-250
Oxidative Damage in Chronic Heart Failure: Protection by Captopril Through Free Radical Scavenging?....Pages 251-255
Free Radical Scavenging Capacity and Anti-Inflammatory Activity of CBS-113 A....Pages 257-259
Mechanism Whereby Different Anti-Oxidants and Lipoxigenase Pathway Inhibitors Suppress IL2 Synthesis....Pages 261-264
Reactive Oxygen Species Released by Human Blood Neutrophils Piroxicam-Treated Healthy Subjects....Pages 265-269
Antioxidative Properties of Met- and Leu-Enkephalin....Pages 271-273
Platelet-Activating Factor Amplifies Tumour Necrosis Factor-Induced Superoxide Generation by Human Neutrophils....Pages 275-282
Comparison of Antioxidant and Prooxidant Activity of Various Synthetic Antioxidants....Pages 283-290
Antioxidant Effects in Radioprotection....Pages 291-300
Nuclear Glutathione Transferases which Detoxify Irradiated DNA....Pages 301-310
Urinary Biomarkers in Radiation Therapy of Cancer....Pages 311-316
Redox Parameters Associated to Cytotoxic and Antitumor Activities in the Series of Antitumor Drugs Ellipticines and Derivatives....Pages 317-322
Peroxidase Induced Metabolism and Lipid Peroxide Scavenging by Antitumor Agents....Pages 323-338
Reduction of Toxicity and Increase of Antitumor Effect of Adriamycin by N-Acyl Dehydroalanines, a New Family of Free Radical Scavengers....Pages 339-344
Inhibition of Bleomycin-Induced Toxic Effects by Antioxidants in Human Malignant Melanoma Cells....Pages 345-348
Are Oxygen Radicals Responsible for the Acute Cardiotoxicity of Doxorubicin?....Pages 349-352
Influence of Selenium on Lipid Peroxidation and Cardiac Functions in Chronically Adriamycin-Treated Rats....Pages 353-359
Improvement of Ischemic and Postischemic Mitochondrial Function by Deferrioxamine : The Role of Iron....Pages 361-366
Allopurinol in Ischemia — Reperfusion Injury of Heart....Pages 367-372
Direct Measurement of Free Radical Generation in Isolated Rat Heart by Electron Paramagnetic Resonance Spectroscopy : Effect of Trimetazidine....Pages 373-376
Effect of a 5 day Trimetazidine Pretreatment in a Model of Ischemic and Reperfused Isolated Rat Heart : Spin Trapping Experiments....Pages 377-382
Antilipoperoxydant Effect of Trimetazidine in Post Ischaemic Acute Renal Failure in the Rat....Pages 383-388
Reperfusion Injury and Renal Metabolism : The Temporal Relationship Between Oxidative Stress and Functional Change....Pages 389-392
Iron Redistribution and Lipid Peroxidation in the Cold Ischaemic Kidney....Pages 393-396
Evidence that Calcium Mediates Free Radical Damage Through Activation of Phospholipase A 2 During Cold Storage of the Rabbit Kidney....Pages 397-400
Ischemia-Reperfusion Injury and Free Radical Involvement in Gastric Mucosal Disorders....Pages 401-410
Zinc-Carnosine Chelate Compound (Z-103) Attenuates Acute Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats....Pages 411-414
Role of Xanthine-Xanthine Oxidase Systems and Polymorphonuclear Leukocytes in Lipid Peroxidation in Compound 48/80-Induced Gastric Mucosal Injury in Rats....Pages 415-418
Effect of the Platelet-Activating Factor (PAF) Antagonist, BN 52021, on Free Radical-Induced Intestinal Ischemia-Reperfusion Damage in the Rat....Pages 419-422
Antioxidant Therapy in Hematological Disorders....Pages 423-433
The Adult Respiratory Distress Syndrome (ARDS) and Oxidative Stress: Therapeutic Implications....Pages 435-448
Antioxidant Activity in Fetal and Neonatal Lung....Pages 449-454
Pro- and Anti-Oxidant Factors in Rat lung Cytosol....Pages 455-461
Oxidants, Joint Inflammation and Anti-Inflammatory Strategies....Pages 463-474
Antioxidant Therapy in Neurological Disorders....Pages 475-484
Free Radicals and Trials of Antioxidant Therapy in Muscle Diseases....Pages 485-491
Parkinson’s Disease and Alzheimer’s Disease :Neurodegenerative Disorders Due to Brain Antioxidant System Deficiency ?....Pages 493-498
Oxidative Stress, Poly(ADP)Ribosylation and Aging: In Vitro Studies on Lymphocytes from Normal and Down’s Syndrome Subjects of Different Age and from Patients with Alzheimer’s Dementia....Pages 499-502
Protein Oxidation and Proteolytic Degradation General Aspects and Relationship to Cataract Formation....Pages 503-511
Free Radicals and Antioxidants in the Pathogenesis of Eye Diseases....Pages 513-527
Singlet Oxygen-Induced Damage to Rat Lenses in Vitro: Protection by Anisyldithiolthione....Pages 529-532
Dermatologic Antioxidant Therapy may be Warranted to Prevent Ultraviolet Induced Skin Damage....Pages 533-536
Antioxidant and Prooxidant effects of the Antipsoriatic Compound Anthralin in Skin and Subcellular Fractions....Pages 537-541
Antioxidant Treatment in Experimental Thermal Injury....Pages 543-549
Production of Superoxide Anion by Glycated Proteins: Involvement in Complications of Diabetes Mellitus....Pages 551-554
Rationale for Antioxidant Therapy in Pancreatitis and Cystic Fibrosis....Pages 555-572
Lipid Peroxidation Levels and Antioxidant Activities of Blood Plasma in Parturients and New-Born Infants Immediatly After Normal Delivery....Pages 573-576
Back Matter....Pages 577-594