Antineoplastic and Immunosuppressive Agents: Part II

Front Matter....Pages I-XXXII
Chemistry of Alkylation....Pages 1-5
Molecular Biology of Alkylation: An Overview....Pages 6-17
Mechanism of Action of 2-Chloroethylamine Derivatives, Sulfur Mustards, Epoxides, and Aziridines....Pages 18-34
Mechanism of Action of Methanesulfonates....Pages 35-46
Mechanism of Action of Mitomycins....Pages 47-64
Mechanism of Action of Nitrosoureas....Pages 65-84
Mechanism of Action of Glucocorticoids....Pages 85-103
Mechanisms of Action of Estrogens....Pages 104-138
Mechanism of Action of Androgens....Pages 139-157
Mechanism of Action of Progesterone....Pages 158-169
Pharmacology and Clinical Utility of Hormones in Hormone Related Neoplasms....Pages 170-192
Fluorinated Pyrimidines and Their Nucleosides....Pages 193-231
Arabinosylcytosine....Pages 232-256
Clinical Pharmacology of Arabinosylcytosine....Pages 257-271
Halogenated Pyrimidine Deoxyribonucleosides....Pages 272-347
Azapyrimidine Nucleosides....Pages 348-372
Showdomycin, 5-Hydroxyuridine, and 5-Aminouridine....Pages 373-383
6-Thiopurines....Pages 384-403
Azathioprine....Pages 404-425
Purine Arabinosides, Xylosides, and Lyxosides....Pages 426-433
Antibiotics Resembling Adenosine: Tubercidin, Toyocamycin, Sangivamycin, Formycin, Psicofuranine, and Decoyinine....Pages 434-457
8-Azaguanine....Pages 458-467
Folate Antagonists....Pages 468-483
Glutamine Antagonists....Pages 484-511
Cytotoxic Amino Acid Analogs....Pages 512-538
Cytotoxic Analogs of Pyridine Nucleotide Coenzymes....Pages 539-543
Triazenoimidazole Derivatives....Pages 544-553
Cytotoxic Inhibitors of Protein Synthesis....Pages 554-570
Selective Interruption of RNA Metabolism by Chemotherapeutic Agents....Pages 571-581
Actinomycin D....Pages 582-592
Daunomycin (Daunorubicin) and Adriamycin....Pages 593-614
Chromomycin, Olivomycin, Mithramycin....Pages 615-622
Nogalamycin....Pages 623-632
Streptonigrin....Pages 633-641
Anthramycin....Pages 642-648
Camptothecin....Pages 649-656
3’-Deoxyadenosine and Other Polynucleotide Chain Terminators....Pages 657-668
Vinca Alkaloids and Colchicine....Pages 686-694
L-Asparaginase: Basic Aspects....Pages 712-722
L-Asparaginase: Current Status of Clinical Evaluation....Pages 742-746
Procarbazine....Pages 747-765
 Bis -Guanylhydrazones....Pages 766-788
Clinical and Pharmacologic Effects of Hydroxyurea....Pages 789-792
α-( N )-Heterocyclic Carboxaldehyde Thiosemicarbazones....Pages 793-807
1-( o -Chlorophenyl)-1-( p -Chlorophenyl)-2,2-Dichloroethane ( o,p ’-DDD), an Adrenocorticolytic Agent....Pages 808-819
The Phthalanilides....Pages 820-828
Platinum Compounds....Pages 829-840
Metal Chelates of 3-Ethoxy-2-Oxobutyraldehyde Bis (Thiosemicarbazone), H 2 KTS....Pages 841-849
Phleomycin and Bleomycin....Pages 850-876
Pharmacology of Newer Antineoplastic Agents....Pages 877-880
Addendum to Cytotoxic Analogs of Pyridine Nucleotide Coenzymes....Pages 891-892
Addendum....Pages 893-894
Back Matter....Pages 893-1070