Antimutagenesis and Anticarcinogenesis Mechanisms III

Front Matter....Pages i-xi
Mechanisms of Antimutagenesis and Anticarcinogenesis: Role in Primary Prevention....Pages 1-16
Multiple Mechanisms: The Example of Vitamin A....Pages 17-25
Inhibition of Nitrosation....Pages 27-44
Protective Mechanisms of Dietary Fibers in Nutritional Carcinogenesis....Pages 45-63
Extracellular Interception of Mutagens....Pages 65-74
Proteins as Scavengers of Nitrite: Antimutagenic Implications....Pages 75-85
Antimutagenic Agents from Natural Products of Terrestrial and Marine Origin....Pages 87-97
Inhibitory Effects of Dietary Leafy Vegetables on Mutagens and on Active Oxygens....Pages 99-102
Extrapolation of in Vitro Antimutagenicity to the in Vivo Situation: The Case for Anthraflavic Acid....Pages 103-110
Preventive Effect of Magnesium Hydroxide on Carcinogen-Induced Large Bowel Carcinogenesis in Rats....Pages 111-118
Antimutagenic Investigations on Commercial Yogurt....Pages 119-125
Chemoprotection by Inducers of Electrophile Detoxication Enzymes....Pages 127-136
Protective Role of Glutathione, Thiols, and Analogues in Mutagenesis and Carcinogenesis....Pages 137-147
N-Acetylcysteine Inhibits Diesel Extract Mutagenicity in the Ames Test and SCE Induction in Human Lymphocytes....Pages 149-160
Sulfotransferase- and Acetyltransferase-Mediated Activation of Carcinogenic N-Hydroxyarylamines in Mammals and Bacteria, and Their Modulation by Thiols....Pages 161-169
Induction of Rat Liver GSH Transferases by 1,2-Dithiole-3-Thione Illustrates Both Anticarcinogenic and Tumor-Promoting Properties....Pages 171-179
Organ-Specific Modification of Carcinogenesis by Antioxidants in Rats....Pages 181-188
The Modulating Effects of Antioxidants in Rat Embryos and Sertoli Cells in Culture....Pages 189-200
Blocking the Plant Activation of Promutagenic Aromatic Amines by Peroxidase Inhibitors....Pages 201-217
Chemoprevention of Rat Liver Carcinogenesis by S-Adenosyl-L-Methionine: Is DNA Methylation Involved?....Pages 219-237
Molecular Control of Human Papillomavirus RNA Expression in Neoplasia....Pages 239-246
The Two umuDC -Like Operons, samAB and umuDC ST , in Salmonella Typhimurium : The umuDC ST Operon may Reduce UV-Mutagenesis-Promoting Ability of the samAB Operon....Pages 247-255
Formation, Inhibition of Formation, and Repair of Oxidative 8-Hydroxyguanine DNA Damage....Pages 257-262
Modulation by Retinoic Acid of Spontaneous and Benzo(A)Pyrene-Induced C -Ha- Ras Expression....Pages 263-268
Identification of Natural Antimutagens with Modulating Effects on DNA Repair....Pages 269-277
Mechanisms of Inhibition of Tumor Progression....Pages 279-289
Histopathology of Human Intraepithelial Neoplasia with Implications for Chemoprevention Strategy....Pages 291-300
Potential Mechanisms of Antitumorigenesis by Protease Inhibitors....Pages 301-307
cDNA Cloning of Serine/Threonine Phosphatase Catalytic Subunits and Reversion of the Malignant Phenotype to the Normal Phenotype by Okadaic Acid, a Protein Phosphatase Inhibitor....Pages 309-316
Mechanisms of Action of New Antitumor Promoters....Pages 317-323
Murine α/β Interferons Inhibit Benzo(A)Pyrene Activation and Mutagenesis in Mice....Pages 325-334
Inhibition of Malignant Tumor Cell Invasion: An Approach to Anti-Progression....Pages 335-350
Direct Interception of Mutagens and Carcinogens by Biomolecules....Pages 351-366
Sphingolipids Inhibit Multistage Carcinogenesis and Protein Kinase C....Pages 367-371
Recent Results in Preclinical and Clinical Drug Development of Chemopreventive Agents at the National Cancer Institute....Pages 373-386
Dietary Inhibitors against Mutagenesis and Carcinogenesis....Pages 387-418
Oxidants and Mitogenesis as Causes of Mutation and Cancer: The Influence of Diet....Pages 419-436
The Growth of Preneoplastic Lesions by 1,2-Dimethylhydrazine in Rat Colon is Inhibited by Dietary Starch....Pages 437-445
Prevention of Genotoxic Effects by Dietary Constituents in Various Organs of Mice Treated with Nitrosamines....Pages 447-457
Effect of Antioxidant Supplementation in an Elderly Population....Pages 459-477
Spontaneous Mutations and Fidelogens....Pages 479-488
Back Matter....Pages 489-494