Antimicrobial drug discovery : emerging strategies

Contents......Page 6
Contributors......Page 8
Dedication......Page 12
Introduction......Page 14
1 Emerging Antimicrobial Drug-discovery Strategies: an Evolving Necessity......Page 20
2 The Antibiotic Crisis......Page 39
3 Structure, Genetic Regulation, Physiology and Function of the AcrAB–TolC Efflux Pump of Escherichia coli and Salmonella......Page 57
4 Small-molecule Efflux Pump Inhibitors from Natural Products as a Potential Source of Antimicrobial Agents......Page 75
5 Fungal Efflux-mediated Resistance: from Targets to Inhibitors......Page 90
6 Vacuolar ATPase: a Model Proton Pump for Antifungal Drug Discovery......Page 102
7 Drug Tolerance, Persister Cells and Drug Discovery......Page 114
8 Inhibition of Quorum Sensing as a Novel Antimicrobial Strategy......Page 128
9 Filamentous Temperature-sensitive Mutant Z (FtsZ) Protein as an Antibacterial Target......Page 148
10 Lysostaphin: a Silver Bullet for Staph......Page 160
11 Strategies to Identify Modified Ribosomally Synthesized Antimicrobials......Page 179
12 Quantitative Structure–Activity Relationship-based Discovery of Antimicrobial Peptides Active Against Multidrug-resistant Bacteria......Page 200
13 Acetyl-CoA Carboxylase as a Target for Antibacterial Development......Page 221
14 Underexploited Targets in Lipopolysaccharide Biogenesis for the Design of Antibacterials......Page 233
15 Predicting and Dissecting High-order Molecular Complexity by Information-driven Biomolecular Docking......Page 245
16 Antifungals and Antifungal Drug Discovery......Page 260
17 Pathosystematic Studies and the Rational Design of Antifungal Interventions......Page 278
18 In Vivo High-throughput Antimicrobial Discovery Screens Utilizing Caenorhabditis elegans as an Alternative Host......Page 305
19 Drosophila melanogaster as a Versatile Model for the Discovery of Drugs Effective against Human Microbe-induced Infection and Pathology......Page 313
20 Antimicrobial Photosensitizers: Harnessing the Power of Light to Treat Infections......Page 323
21 Nanoparticle Platforms for Antimicrobial Therapy......Page 336
22 Antimicrobial Activity of Carbon Nanotubes......Page 351
A......Page 362
C......Page 363
E......Page 364
H......Page 365
L......Page 366
N......Page 367
P......Page 368
S......Page 369
Z......Page 370