Antimetabolites in Biochemistry, Biology and Medicine. Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10–12, 1978

Content: 
Proceedings of the 12th FEBS Meeting, Page ii
Front Matter, Page iii
Copyright, Page iv
INTRODUCTORY REMARKS, Pages ix-x, Jan Škoda
Recent Studies on the Interaction of 5-Fluoro-2′-deoxyuridylate with Thymidylate Synthetase, Pages 3-19, P.V. Danenberg, A. Lockshin, K.D. Danenberg
THE SITE OF ACTION OF FLUOROURACIL IN RELATION TO THE AMINO ACID SEQUENCE OF THYMIDYLATE SYNTHETASE, Pages 21-31, Frank Maley, Gladys F. Maley
PHARMACOLOGY OF 5-AZA-2′-DEOXYCYTIDINE, Pages 33-41, Richard L. Momparler
INHIBITORS OF THYMIDYLATE SYNTHETASE, Pages 43-53, Daniel V. Santi, Yusuke Wataya, Akira Matsuda
THE DEVELOPMENT OF γ-(N)-HETEROCYCLIC CARBOXALDEHYDE THIOSEMICARBAZONES AS INHIBITORS OF RIBONUCLEOTIDE REDUCTASE, Pages 55-63, Alan C. Sartorelli
TRANSFORMATION AND INCORPORATION OF 5-AZA-2′-DEOXYCYTIDINE IN THE LYMPHATIC SYSTEM, Pages 65-74, Jirí Veselý
THE EFFECT OF 5-FLUOROPYRIMIDINES ON THE PROCESSING OF RIBONUCLEIC ACIDS IN LIVER, Pages 77-85, A.A. Hadjiolov, K.V. Hadjiolova
THE INTERACTIONS OF BrdU-SUBSTITUTED DNA WITH LAC REPRESSOR AND HISTONES, Pages 87-113, Syr-Yaung Lin
THE INCORPORATION OF HYDROXYMETHYLDEOXYURIDINE INTO DNA OF EHRLICH ASCITES CARCINOMA CELLS AND SOME OF ITS CONSEQUENCES, Pages 115-126, E. Matthes, D. Bärwolff, B. Preussel, P. Langen
THE EFFECT OF SUBSTRATE MODIFICATION ON TRANSCRIPTION OF DNA BY DNA-DEPENDENT RNA POLYMERASE, Pages 127-138, Karl Heinz Scheit
SOME STRUCTURAL ASPECTS OF NUCLEOSIDE ANTIMETABOLITES, WITH PARTICULAR REFERENCE TO TAUTOMERISM AND CONFORMATION, Pages 139-149, David Shugar
TRANSITION STATE ANALOGS AS ANTIMETABOLITES, Pages 151-160, Richard Wolfenden
ANTIMETABOLITES IN CANCER CHEMOTHERAPY: PAST, PRESENT AND FUTURE, Pages 163-176, Alexander Bloch
APPROACHES TO IMPROVED THERAPEUTIC SELECTIVITY WITH METHOTREXATE, Pages 177-190, Gerald B. Grindey, Judith A. Hoglind, Richard G. Moran
RATIONAL USE OF ANTIMETABOLITES OF SPECIFIC AMINO ACIDS IN COMBINATION CHEMOTHERAPY OF CANCER, Pages 191-201, Ladislav J. Haňka
SELECTIVITY OF ANTICANCER DRUG ACTION IN THE MODULATION OF THE IMMUNE RESPONSE, Pages 203-210, E. Mihich, M.J. Ehrke, C.C. Hoffman, V. Tomazic, S.A. Cohen, D. Bogyo
SYNTHESIS, ANTINEOPLASTIC EFFECT IN ANIMALS WITH EXPERIMENTAL TUMOURS, AND SOME OTHER BIOLOGICAL PROPERTIES OF COMPOUND 9777-VÚFB (DAMVAR), Pages 211-217, Miroslav Semonský, Antonín Çerný, Jiří Křepelka, Vojtêch Pujman, Karel Řežábek, Vlasta Francová, Otakar Andrysek, Soňa Semonská
LOCALIZED CHEMOTHERAPY OF SOLID EXPERIMENTAL TUMORS WITH MACROMOLECULAR CARRIERS CONTAINING ANTIFOLATES, Pages 219-231, K. Slavík, K. Motyçka, V. Slavíková
RATIONAL USE OF ANTIMETABOLITES IN CANCER CHEMOTHERAPY WITH SPECIAL REFERENCE TO HIGH DOSE METHOTREXATE/CITROVORUM FACTOR RESCUE THERAPY, Pages 233-245, Wolfgang Wilmanns, Hansjörg Sauer
SELECTIVE INHIBITION OF ONCORNAVIRAL FUNCTIONS (A MOLECULAR APPROACH), Pages 249-261, PRAKASH CHANDRA
STRATEGY FOR THE DEVELOPMENT OF SELECTIVE ANTIHERPES VIRUS AGENTS BASED ON THE UNIQUE PROPERTIES OF VIRAL INDUCED ENZYMES—THYMIDINE KINASE, DNase AND DNA POLYMERASE, Pages 263-274, Yung-chi Cheng
COMPARATIVE STUDY OF THE POTENCY AND SELECTIVITY OF ANTI-HERPES COMPOUNDS, Pages 275-285, E. De Clercq, J. Descamps, P.J. Barr, A.S. Jones, P. Serafinowski, R.T. Walker, G.F. Huang, P.F. Torrence, C.L. Schmidt, M.P. Mertes, T. Kulikowski, D. Shugar
MOLECULAR BASIS FOR SERENDIPITOUS DEVELOPMENT OF ANTIVIRAL AND ANTICANCER AMINONUCLEOSIDES, Pages 287-293, William H. Prusoff, Ming S. Chen, Paul Fischer, Tai-Shun Lin, George T. Shiau, Raymond F. Schinazi, Jamieson Walker
SOME CONSEQUENCES OF INHIBITION OF THE DE NOVO PATHWAY OF PYRIMIDINE BIOSYNTHESIS, Pages 297-303, R.E. Handschumacher, P.M. Schwartz, J.D. Moyer
MANIPULATION OF PURINE NUCLEOTIDE CONCENTRATIONS BY ANTIMETABOLITES, Pages 305-313, J. Frank Henderson
MOLECULAR TARGETS FOR METHOTREXATE, Pages 315-326, C. Fan, G. Henderson, K. Vitols, F.M. Huennekens
RATIONAL DESIGN OF ANTI-HERPES VIRUS ANTI-METABOLITES, Pages 327-341, Werner E.G. Müller
SEARCH FOR NEW ANTIMETABOLITES AND NEW LATENT FORMS OF METABOLITES AND ANTIMETABOLITES AMONG THE NUCLEOSIDE ALKYLPHOSPHONATES, Pages 343-351, M.N. Preobrazhenskaya, S.Ya. Melnik, G.I. Vornovitskaya, T.P. Nedorezova, I.D. Shingarova
“3-OXAPYRIMIDINES” (DERIVATIVES OF 2, 3-DI-HYDRO-1, 3—6H-OXAZINE) - A NEW CATEGORY OF ANTIMETABOLITES WITH A SHORT HALF-LIFE, Pages 353-367, Jan Ŝkoda, Ivan Votruba, Jiří Farkaŝ
AUTHOR INDEX, Pages 369-370
SUBJECT INDEX, Pages 371-374