Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies: Workshop Summary

Cover......Page 1
Antibiotic Resistance: Implications for Global Health and Novel Intervention Strategies......Page 2
Copyright......Page 3
National Academy of Sciences......Page 5
FORUM ON MICROBIAL THREATS......Page 6
BOARD ON GLOBAL HEALTH......Page 8
Reviewers......Page 10
Acknowledgments......Page 12
Contents......Page 14
Tables, Figures, and Boxes......Page 18
Workshop Overview......Page 24
A1 The case for pathogen-specific therapy......Page 98
A2 Waves of resistance : Staphylococcus aureus in the antibiotic era......Page 106
A3 Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis......Page 139
A4 Antibiotic-induced resistance flow......Page 164
A5 Act inobacteria: the good, the bad, and the ugly......Page 172
A6 Antibiotics for Emerging Pathogens......Page 183
A7 AVERTING A POTENTIAL POST-ANTIBIOTIC ERA......Page 197
A8 Antibiotic Effectiveness : New Chalenges in Natural Resource Management......Page 213
A9 The role of health care facilities......Page 229
A10 Responding to the Global Antibiotic Resistance Crisis : The APUA Chapter Network......Page 245
A11 CHALLENGES AND OPPORTUNITIES IN ANTIBIOTIC DISCOVERY......Page 256
A12 Population Mobility, Globalization, and Antimicrobial Resistance......Page 280
A13 Population Mobility, Globalization, and Antimicrobial Drug Resistance ......Page 299
A14 THE BACTERIAL CHALLENGE: A TIME TO REACT, EXECUTIVE SUMMARY......Page 310
A15 THE EFFECTS OF ANTIBIOTIC AND PESTICIDE RESISTANCE ON PUBLIC HEALTH......Page 317
A16 Clinical Issues and Outcomes Associated with Rising Antimicrobial Resistance......Page 324
A17 WORLD HEALTH ORGANIZATION activities for controlof antimicrobial resistance due to use ofantimicrobials in animals intended for food......Page 331
A18 The antibacterial pipeline: why is it drying up, and what must be done about it......Page 349
A19 Challenges in Antimicrobial Susceptibility Testing of Clinical and Environmental Isolates......Page 388
A20 Measuring the Cost of Antimicrobial -Resistant Infections : The Feasibility and Accuracy of Economic Analysis Using Electronic Medical Record Databases......Page 402
A21 The antibiotic resistome......Page 424
Appendix B Agenda......Page 443
Appendix C Acronyms......Page 447
Appendix D Glossary......Page 450
Appendix E Forum Member Biographies......Page 460
Appendix F Speaker Biographies......Page 488