Angiogenesis: Molecular Biology, Clinical Aspects

Front Matter....Pages i-x
Embryology of the Endothelial Network: Is There an Hemangioblastic Anlage ?....Pages 1-8
Cellular and Molecular Biology of Endothelial Cell Differentiation during Embryonic Development....Pages 9-14
Endothelial Cell Heterogeneity and Organ — Specificity....Pages 15-28
Inhibitors of Neovascularization: Critical Mediators in the Coordinate Regulation of Angiogenesis....Pages 29-37
Human Basic Fibroblast Growth Factor: Structure-Function Relationship of an Angiogenic Molecule....Pages 39-50
Angiogenesis Models Identify Factors Which Regulate Endothelial Cell Differentiation....Pages 51-60
EMA-1, a Novel Endothelial Cell Surface Molecule That is Preferentially Expressed by Migrating Endothelial Cells....Pages 61-65
Early Response Genes in Endothelial Cells....Pages 67-72
P1GF: Placenta Derived Growth Factor....Pages 73-80
Expression of the M-Subunit of Laminin Correlates with Increased Cell Adhesion and Metastatic Propensity....Pages 81-89
The Proliferative Effect of Substance P on Capillary Endothelial Cells is Mediated by Nitric Oxide....Pages 91-96
Reactivation of Metalloproteinase-Inhibitor Complex by a Low Molecular Mass Angiogenic Factor....Pages 97-101
Interactions between Oxidized Lipoprotein (a) [Lp(a)], Monocytes and Endothelial Cells....Pages 103-109
Altered Proliferation of Retinal Microvascular Cells in Response to Non-Enzymatic Glycosylated Matrix Proteins....Pages 111-118
A Novel Laminin Domain Involved in Adhesion of Endothelial Cells....Pages 119-123
Regulation of Angiogenesis: The Role of Protein Kinase, Nitric Oxide, Thrombin and Basement Membrane Synthesis....Pages 125-134
Basement Membrane Laminin-Derived Peptide Sikvav Promotes Angiogenesis and Tumor Growth....Pages 135-141
Release of Gangliosides in the Microenvironment and Angiogenic Response in Vivo....Pages 143-147
Angiogenesis in Vitro: Cytokine Interactions and Balanced Extracellular Proteolysis....Pages 149-170
Endothelial Plasminogen Activators and Matrix Metalloproteinases in Fibrinolysis and Local Proteolysis....Pages 171-181
Tumor Antiangiogenesis: Which Way?....Pages 183-191
Therapeutic Angiogenesis in Surgery and Oncology....Pages 193-207
Endothelial Cell Stimulating Angiogenesis Factor in Relation to Disease Processes....Pages 209-217
Hyaluronan and Angiogenesis: Molecular Mechanisms and Clinical Applications....Pages 219-231
Chronic Cellular Injury and Human Proliferative Disorders....Pages 233-238
Cellular and Molecular Mechanisms of Angiogenesis in the Brain....Pages 239-244
Angiogenesis and Fibrin Degradation in Human Breast Cancer....Pages 245-252
Thrombin-Mediated Events Implicated in Post-Thrombotic Recovery....Pages 253-263
Anti-Tumor Effects of GBS Toxin are Caused by Induction of a Targeted Inflammatory Reaction....Pages 265-269
Biological Data and Docking Experiments of bFGF-Sulfonated Distamycin a Derivative Complex....Pages 271-276
Clinical Ocular Angiogenesis....Pages 277-282
In Vivo Assays for Angiogenesis....Pages 283-289
Quantitative Analysis of Extracellular Matrix Formation in Vivo and in Vitro ....Pages 291-305
Micro Vascular Morphometry....Pages 307-313
The Corneal Model for the Study of Angiogenesis....Pages 315-320
Factitious Angiogenesis: Not so Factitious Anymore? The Role of Angiogenic Processes in the Endothelialization of Artificial Cardiovascular Prostheses....Pages 321-331
Some Problems of Trial Design for Anti-Angiogenic Agents in Cancer Therapy....Pages 333-358
Back Matter....Pages 360-372