Angiogenesis: Models, Modulators, and Clinical Applications

Front Matter....Pages i-x
Introductory Comments....Pages 1-4
Front Matter....Pages 5-5
Microvascular Endothelial Cells from Adrenal Medulla — A Model for in Vitro Angiogenesis....Pages 7-18
Angiogenesis in the Heart and Skeletal Muscle — Models for Capillary Growth....Pages 19-33
Basement Membrane Biosynthesis as a Biochemical Index of Angiogenesis in Chick Chorioallantoic Membrane....Pages 35-38
The Rat and the Rabbit Cornea Assay....Pages 39-46
The Rat Aorta Model of Angiogenesis: Methodology and Applications....Pages 47-53
Assessment of Angiogenesis by MRI....Pages 55-60
Measuring Intratumoral Microvessel Density....Pages 61-74
Patterns of Physiological Angiogenesis in Adult Mesentery....Pages 75-84
Angiogenesis — Critical Assessment of in-Vitro Assays and in — Vivo Models....Pages 85-89
Front Matter....Pages 91-91
The Several Roles for Oxygen in Wound Angiogenesis....Pages 93-98
Autocrine Role of Basic Fibroblast Growth Factor (bFGF) in Angiogenesis and Angioproliferative Diseases....Pages 99-112
Inflammatory Angiogenic Factors in a Model of Chronic Inflammation....Pages 113-120
Angiogenic Mediators in Wound Healing....Pages 121-128
Modulation of Vascular Endothelial Growth Factor Angiogenic Activity by ADP-Ribosylation....Pages 129-135
Role of Fibroblast Growth Factor -2 and Endothelial Cell Stimulating Angiogenic Factor (ESAF) in Capillary Growth in Skeletal Muscles Exposed to Long-Term High Activity....Pages 137-147
Angiogenesis in Atherosclerosis: Possible Roles for Vascular Endothelial Cell Growth Factor, Endothelial Cell Stimulating Angiogenesis Factor and Soluble E-Selectin....Pages 149-155
Thymosin Beta 4 Promotes Endothelial Cell Migration and Angiogenesis....Pages 157-163
Structural Studies on Angiogenin, a Protein Implicated in Neovascularization during Tumour Growth....Pages 165-178
Lesional Levels of Endothelial Cell Stimulating Angiogenesis Factor (ESAF) and Vascular Endothelial Cell Stimulating Angiogenesis Factor (VEGF) are Elevated in Psoriasis....Pages 179-184
Front Matter....Pages 185-185
Structure and Functional Role of Endothelial Cell-to-Cell Junctions....Pages 187-201
The Interaction of Human Neutrophils with Type IV Collagen Involves an Inhibitory Signal Transduction Pathway....Pages 203-211
Angiogenic Polypeptides in Breast Cancer: Expression of Mrna’s in Primary Human Tumours, MCF-7 Cell Transfection and Xenograft Models....Pages 213-221
Front Matter....Pages 223-223
The Role of Thrombin and Its Receptors in Angiogenesis. Physiological and Pathological Applications....Pages 225-232
Fibrin Degradative Pathways and Angiogenesis in Healing, Atherosclerosis and Tumour Invasion....Pages 233-240
Proteases and Angiogenesis. Regulation of Plasminogen Activators and Matrix Metalloproteases by Endothelial Cells....Pages 241-261
Cellular and Molecular Effects of Thrombin in the Vascular System....Pages 263-282
Front Matter....Pages 283-283
Endogenous Regulation of Angiogenesis in Vitro ....Pages 285-296
Nitric Oxide and Angiogenesis....Pages 297-306
Nitric Oxide: A Promoter or Inhibitor of Angiogenesis....Pages 307-319
Hypoxia/Reoxygenation Enhances Tube Formation of Cultured Human Microvascular Endothelial Cells: the Role of Reactive Oxygen Species....Pages 321-336
Tumour Angiogenesis and Metastasis: The Regulatory Role of Hyaluronan and Its Degradation Products....Pages 337-347
Cytokines and Growth Factors. Early Gene Expression During Angiogenic Stimuli....Pages 349-353
The Role of the Laminin Peptide SIKVAV in the Revascularization of Ischemic Tissue....Pages 355-365
Oxidized Lipoproteins Enhance the in Vitro Tube Formation by Endothelial Cells Cultured on Matrigel....Pages 367-375
A Peptied From the NC1 Domain of the α3 Chain of Type IV Collagen Prevents Damage to Basement Membranes by PMN....Pages 377-386
Front Matter....Pages 387-387
Tumoral Vascularity: What Does It Tell Us About the Growth and Spread of Cancer?....Pages 389-405
Tumor Vascularity, Hypoxia, and Malignant Progression in Solid Neoplasms....Pages 407-414
Scatter Factor as a Mediator of Tumor Angiogenesis....Pages 415-426
Front Matter....Pages 427-427
The Vascularization of Experimental and Human Primary Tumors: Comparative Morphometric and Morphologic Studies....Pages 429-447
Front Matter....Pages 427-427
“CM101 — An Anti-Pathoangiogenic Agent: Pre-Clinical and Clinical Experiences”....Pages 449-457
Mapping Neovascularization and Antineovascularization Therapy....Pages 459-473
Clinical Trials of Angiogenesis-Based Therapies: Overview and New Guiding Principles....Pages 475-492
Abstracts of Posters....Pages 493-557
Back Matter....Pages 558-571