Amyotrophic Lateral Sclerosis: Therapeutic, Psychological, and Research Aspects

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Deficient Repair of Alkylation Damage of DNA in Alzheimer’s Disease and Amyotrophic Lateral Sclerosis Cells....Pages 3-6
Immunoglobulin-Mediated Cytotoxic Effect of ALS-Plasma Towards Erythrocytes: Reflexion of a Pathogenetic Mechanism?....Pages 7-13
Differentiation of Human Muscle Cells in the Presence of Neuronal Conditioned Medium (NCM), Nerve Growth Factor (NGF) and Spinal Cord Cells (SC)....Pages 15-17
GM2 Gangliosidosis with a Motor Neuron Disease Phenotype: Clinical Heterogeneity of Hexosaminidase Deficiency Disease....Pages 19-23
Addendum....Pages 23-23
Proteases, Their Inhibitors and the Extracellular Matrix: Factors in Nerve-Muscle Development and Maintenance....Pages 25-39
The Role of Axoplasmic Transport in the Restoration of Synaptic Transmission and in the Process of Sprouting During Nerve Regeneration....Pages 41-49
Purification of a Survival Factor for Spinal Neurons from Mouse Salivary Gland....Pages 51-58
Neurite-Promoting Factors for Spinal Neurons: Their Possible Importance for the Understanding of Amyotrophic Lateral Sclerosis and the Spinal Muscular Atrophies....Pages 59-64
Human Spinal Cord Neurons in Culture as a Tool to Study Amyotrophic Lateral Sclerosis....Pages 65-70
Autoimmune Involvement in Motor Neurone Disease....Pages 71-73
Cytotoxicity of Serum from Amyotrophic Lateral Sclerosis Patients on Spinal Cord Cells in Culture....Pages 75-77
ALS Cerebrospinal Fluid Enhances Human Foetal Astroglial Cell Proliferation in Vitro ....Pages 79-81
The Electromyographic, Physiopathogenetic Evaluation of Amyotrophic Lateral Sclerosis....Pages 83-87
The Pathogenetic Role of Metals in Motor Neuron Disease — The Participation of Aluminum....Pages 89-96
Front Matter....Pages 97-97
The Syndromic Nature of Amyotrophic Lateral Sclerosis....Pages 99-107
Familial ALS: Clinical, Genetic and Morphological Features....Pages 109-110
Light and Ultrastructural Studies in Sural Biopsies of the Pseudopolyneuropathic form of ALS....Pages 111-119
Prosody Alterations in Amyotrophic Lateral Sclerosis....Pages 121-123
Analysis of Extrinsic Factors Affecting Pallestesic Threshold (VT) Of Amyotrophic Lateral Sclerosis Patients....Pages 125-128
Front Matter....Pages 97-97
Spinal Cord Electrophysiological Activities After Small Doses of TRH in Control Subjects and ALS Patients....Pages 129-133
Osmotic Haemolysis in Amyotrophic Lateral Sclerosis....Pages 135-137
Some Remarks on Lung Function in Amyotrophic Lateral Sclerosis....Pages 139-142
CT-Scanning of Skeletal Muscles in Amyotrophic Lateral Sclerosis....Pages 143-148
Immunological Assessment in Sporadic Amyotrophic Lateral Sclerosis (ALS)....Pages 149-153
Changes in the Normal Pattern of H-Reflex Inhibition During Muscle Release in ALS....Pages 155-158
Atypical Forms of Familial Amyotrophic Lateral Sclerosis....Pages 159-164
Front Matter....Pages 165-165
The Management of Motor Neurone Disease....Pages 167-174
The Treatment of Amyotrophic Lateral Sclerosis....Pages 175-182
Nutritional Supplements in Amyotrophic Lateral Sclerosis....Pages 183-189
Respiratory Monitoring and Treatment: Objective Treatments Using Non-Invasive Measurements....Pages 191-200
Management of Bulbar Symptoms in Amyotrophic Lateral Sclerosis....Pages 201-221
Clinico-Pathological Studies of Long Survival ALS Cases Maintained by Active Life-Support Measures....Pages 223-225
First Results with Percutaneous Endoscopic Gastrostomy....Pages 227-229
Home Nursing Care by Families for Severely Paralyzed ALS Patients....Pages 231-238
Physical Therapy and Rehabilitation Techniques for Patients with Amyotrophic Lateral Sclerosis....Pages 239-252
Front Matter....Pages 253-253
A Study of Prognostic Factors in Motor Neuron Disease....Pages 255-263
Therapeutic Trials in ALS — The Design of a Protocol....Pages 265-276
Attempted Treatment of Motor Neuron Disease with N-Acetylcysteine and Dithiothreitol....Pages 277-280
Therapeutic Trial with N-Acetylcysteine in Amyotrophic Lateral Sclerosis....Pages 281-284
Front Matter....Pages 253-253
A Follow-Up Electromyographic Investigation of ALS Patients Treated with High Dosage Gangliosides....Pages 285-290
A Therapeutic Trial of a Thymic Factor in Amyotrophic Lateral Sclerosis (ALS)....Pages 293-296
Antiviral Therapy....Pages 297-304
Therapeutic Trial of Intrathecal Thyrotropin-Releasing Hormone (TRH) and a TRH-Analogue in Amyotrophic Lateral Sclerosis (ALS)....Pages 305-308
Front Matter....Pages 309-309
Psychological Preparation of the Physician for ALS Patients....Pages 311-312
Psychodynamic Aspects in Patients with Amyotrophic Lateral Sclerosis (ALS)....Pages 313-316
Severity Stages of ALS and Psychological Management....Pages 317-318
On Behalf of the Patient....Pages 319-322
Front Matter....Pages 323-323
Motor Neuron Disease: Epidemiologic Studies....Pages 325-332
Epidemiology of Motor Neuron Disease in North-East Veneto Region: Venice, Padua, and Belluno Provinces (1972 – 1981)....Pages 333-337
Amyotrophic Lateral Sclerosis in Limousin (Limoges Area — France)....Pages 339-339
Amyotrophic Lateral Sclerosis in Finland....Pages 341-344
Amyotrophic Lateral Sclerosis in Nova Scotia....Pages 345-349
Back Matter....Pages 351-357