Amyotrophic Lateral Sclerosis

00_preface_Amyotrophic Lateral Sclerosis......Page 1
00x_part1......Page 21
01_Amyotrophic Lateral Sclerosis:\rAn Introduction to Treatment and Trials......Page 23
02_Insights Arising from Gene Expression Profiling\rin Amyotrophic Lateral Sclerosis......Page 61
03_Dynamic Meta-Analysis as a Therapeutic\rPrediction Tool for Amyotrophic\rLateral Sclerosis......Page 79
04_In Vivo and In Vitro Models to Study Amyotrophic Lateral Sclerosis......Page 101
05_Advantages and Pitfalls in\rExperimental Models Of ALS......Page 145
06_Electrophysiological Abnormalities in SOD1\rTransgenic Models in Amyotrophic Lateral\rSclerosis: The Commonalities and Differences......Page 177
07_Molecular and Electrical Abnormalities in the\rMouse Model of Amyotrophic Lateral Sclerosis......Page 195
07x_part2......Page 215
08_Role of Mitochondrial Dysfunction in Motor\rNeuron Degeneration in ALS......Page 217
09_Role of Neuronal Mitochondrial Metabolic\rPhenotype in Pathogenesis of ALS......Page 245
10_Mutant Cu/Zn-Superoxide Dismutase Induced\rMitochondrial Dysfunction in Amyotrophic\rLateral Sclerosis......Page 269
11_Folding and Aggregation of\rCu, Zn-Superoxide Dismutase......Page 285
12_Oxidative Modifications of Cu, Zn-Superoxide\rDismutase (SOD1) – The Relevance to\rAmyotrophic Lateral Sclerosis (ALS)......Page 321
13_Reactive Nitrogen Species in\rMotor Neuron Apoptosis......Page 333
14_Protein Aggregates in Pathological Inclusions\rof Amyotrophic Lateral Sclerosis......Page 355
15_The Kynurenine Pathway......Page 377
15x_part3......Page 395
16_The Astrocytic Contribution in ALS:\rInflammation and Excitotoxicity......Page 397
17_Innate Immunity in ALS......Page 413
18_The Role of TNF-Alpha in ALS: New Hypotheses\rfor Future Therapeutic Approaches......Page 433
19_Stem Cell Application for Amyotrophic\rLateral Sclerosis: Growth Factor\rDelivery and Cell Therapy......Page 457
20_Glial Cells as Therapeutic Targets for ALS......Page 475
20x_part4......Page 497
21_Genetics of Amyotrophic Lateral Sclerosis......Page 499
22_Genetics of Familial\rAmyotrophic Lateral Sclerosis......Page 537
23_A Major Genetic Factor at Chromosome 9p\rImplicated in Amyotrophic Lateral Sclerosis\r(ALS) and Frontotemporal Lobar Degeneration\r(FTLD)......Page 557
23x_part5......Page 575
24_Multidisciplinary Rehabilitation in\rAmyotrophic Lateral Sclerosis......Page 577
25_Assessment and Management of Respiratory\rDysfunction in Patients with Amyotrophic\rLateral Sclerosis......Page 599
26_Nutritional Care in Amyotrophic Lateral\rSclerosis: An Alternative for the Maximization of\rthe Nutritional State......Page 615
27_How to Assess Disease’s Severity and Monitor\rPatients with Amyotrophic Lateral Sclerosis:\rLessons From Neurophysiology......Page 633
28_Protection of Motor Neurons in\rPre-Symptomatic Individuals Carrying SOD 1\rMutations: Results of Motor Unit Number\rEstimation (MUNE) Electrophysiology......Page 647
29_Communication Impairment in ALS Patients\rAssessment and Treatment......Page 685
30_Human Computer Interactions for Amyotrophic\rLateral Sclerosis Patients......Page 703
31_Overview of Cognitive Function in ALS, with\rSpecial Attention to the Temporal Lobe:\rSemantic Fluency and Rating the\rApproachability of Faces\r......Page 723