Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Aspects of the History and Nomenclature of Amyloid and Amyloidosis....Pages 3-8
Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis....Pages 9-29
AA Amyloidosis....Pages 31-53
Leukocyte Cell-Derived Chemotaxin 2 Amyloidosis (ALECT2)....Pages 55-63
The Hereditary Amyloidoses....Pages 65-80
Dialysis-Associated Amyloidosis....Pages 81-94
Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System....Pages 95-120
Amyloid Deposition in the Central Nervous System....Pages 121-131
Front Matter....Pages 133-133
Differential Diagnosis of Amyloid in Surgical Pathology: Organized Deposits and Other Materials in the Differential Diagnosis of Amyloidosis....Pages 135-152
Light/Heavy Chain Deposition Disease as a Systemic Disorder....Pages 153-166
Non-Randall Glomerulonephritis with Non-Organized Monoclonal Ig Deposits....Pages 167-178
Pathologies of Renal and Systemic Intracellular Paraprotein Storage: Crystalopathies and Beyond....Pages 179-194
Front Matter....Pages 195-195
Diagnosis of Amyloid Using Congo Red....Pages 197-211
Diagnosis of Minimal Amyloid Deposits by Congo Red Fluorescence and Amyloid Type-Specific Immunohistochemistry: A Review....Pages 213-224
Thioflavin T Stain: An Easier and More Sensitive Method for Amyloid Detection....Pages 225-227
Fat Tissue Analysis in the Management of Patients with Systemic Amyloidosis....Pages 229-248
Generic Diagnosis of Amyloid: A Summary of Current Recommendations and the Editor’s Comments on Chapters 13–16....Pages 249-259
Typing of Amyloid for Routine Use on Formalin-Fixed Paraffin Sections of 626 Patients by Applying Amyloid type-Specific Immunohistochemistry: A Review....Pages 261-272
Amyloid Typing: Experience from a Large Referral Centre....Pages 273-282
Options for Amyloid Typing in Renal Pathology: The Advantages of Frozen Section Immunofluorescence and a Summary of General Recommendations Regarding Immunohistochemistry Methods....Pages 283-293
Front Matter....Pages 195-195
Amyloid Typing in Plastic-Embedded Tissue by Immune-Gold-Silver Method....Pages 295-298
The Role of Immuno-Electron Microscopy in Amyloid Typing: The Experience of the Pavia Referral Center....Pages 299-310
Classification of Amyloidosis by Mass Spectrometry-Based Proteomics....Pages 311-322
The Role of Differential Proteomics in Amyloid Typing: The Experience of the Pavia Referral Center....Pages 323-330
Front Matter....Pages 331-331
Laboratory Support for Diagnosis of Amyloidosis....Pages 333-341
Bone Marrow Biopsy and Its Utility in the Diagnosis of AL Amyloidosis....Pages 343-353
Laboratory Methods for the Diagnosis of Hereditary Amyloidoses....Pages 355-366
Front Matter....Pages 367-367
Amyloidoses of the Kidney, the Lower Urinary and Genital Tracts (Male and Female), and the Breast....Pages 369-389
Cardiac Amyloidosis....Pages 391-411
Amyloidosis of the Gastrointestinal Tract and Liver....Pages 413-435
Peripheral Nerve Amyloidosis....Pages 437-450
Amyloidosis of the Lymph Nodes and the Spleen....Pages 451-458
Amyloidosis of the Lung....Pages 459-467
Cutaneous Amyloidosis....Pages 469-479
Iatrogenic Pharmaceutical Amyloidosis Associated with Insulin and Enfuvirtide Administration....Pages 481-485
Front Matter....Pages 487-487
Clinical and Pathologic Issues in Patients with Amyloidosis: Summary and Practical Comments Regarding Diagnosis, Therapy, and Solid Organ Transplantation....Pages 489-505
Emerging Therapies for Amyloidosis....Pages 507-511
Modern Therapies in AA Amyloidosis....Pages 513-517
Medicolegal Issues of Amyloidosis....Pages 519-524
Amyloidosis from the Patient’s Perspective....Pages 525-529
Back Matter....Pages 531-542