Amyloid and Amyloidosis

Front Matter....Pages i-xx
Front Matter....Pages 1-1
A Brief History of International Symposia on Amyloidosis....Pages 3-8
Statistical Analysis of Amyloid Activities Since 1950 — Basis for an Autonomous Journal....Pages 9-14
Front Matter....Pages 15-15
Anti-Casein Antibodies in the Serum of Patients with Al Amyloidosis....Pages 17-22
Experimental Systemic Amyloidosis in Mice-Induction of Amyloidosis by Immunization with Syngeneic Organ Extracts and Immunological Investigation....Pages 23-28
Secondary Amyloidosis Associated with Chronic Arthritis in Rabbits....Pages 29-34
Cloning and Sequence Analysis of cDNAs Encoding Mouse C-Reactive Protein....Pages 35-40
Systemic Amyloidosis: Tissue Specific Variability in the Primary Structure of Amyloid Proteins....Pages 41-43
Fourier Transform Infrared Spectroscopy of Air-Dried and Heavy Water Suspended AA and AL Amyloid Fibril Preparations of Different Species....Pages 45-50
Replacement of SAA from the HDL-SAA Complex by APO AI and APO AII: HDL has Higher Binding Capacity for SAA than for AA....Pages 51-56
apoSAA and AA: Precursor and Product Revisited....Pages 57-62
SAA2 Deposition in the Spleen of the Mouse....Pages 63-68
In Vitro Formation of Amyloid Fibrils from Murine Serum Amyloid a Protein (SAA)....Pages 69-73
Induced AA Amyloid in Hamster: On the Amyloid Enhancing Factor and Protein AA-Cross Reacting Components of Intermediate Molecular Weight....Pages 75-80
Deposition of Amyloid a Fibrils in Spleen is Accompanied by Decreased Hepatic and Splenic and Increased Macrophage Serum Amyloid a Expression....Pages 81-86
Immunolocalization of Heparan Sulfate Proteoglycans to AA Amyloid Deposition Sites in Spleen and Liver During Experimental Amyloidosis....Pages 87-93
Renal Peritubular Amyloid Deposition in the Experimental Murine Amyloidosis....Pages 95-100
Ultrastructural Study of the Spleen in Experimental Murine Amyloidosis Using the Protein A-Gold Immunocytochemical Technique....Pages 101-106
Experimental Amyloidosis of Rabbit Induced by Saponin....Pages 107-112
Ultrastructural Investigation of Spontaneously Occurring Amyloidosis in White Pekin Ducks....Pages 113-118
Enhanced Degradation of Serum Amyloid Protein SAA in vivo by Proteolytic Enzymes....Pages 119-124
Front Matter....Pages 15-15
Degradation Studies on Plasma Prealbumin....Pages 125-130
Protease and Protease Inhibitors in Familial Amyloidotic Polyneuropathy....Pages 131-135
A Study of Dipeptidyl Aminopeptidase IV in the Sera of Japanese FAP Patients....Pages 137-142
Front Matter....Pages 143-143
Primary Structure of A V K II Light Chain from a Patient with Amyloid Arthropathy....Pages 145-150
Molecular Heterogeneity of Amyloid Fibril Proteins in Primary Amyloidosis....Pages 151-156
The Amino Acid Sequence of a Carbohydrate-Containing Immuno-Globulin-Light-Chain-Type Amyloid Fibril Protein (AL)....Pages 157-162
Structural Analysis of a Lambda IV Primary Amyloid Protein....Pages 163-168
AL Amyloidosis (MIY) with Intestinal Tract Involvements and the Chemical Analysis of its BJP (MIY, NIG-84)....Pages 169-173
Lambda Predominance of Bence Jones Protein (BJP) in AL Amyloidosis Among Japanese Patients....Pages 175-178
Immunohistochemical Typing of Tissues from 100 Patients with Systemic Amyloidosis....Pages 179-184
Expression of Plasma Cell-Associated Non-Light Chain Antigens in Patients with Plasma Cell Dyscrasia and Amyloidosis....Pages 185-190
Use of Various Electroimmune Techniques in the Diagnosis and Follow-Up of Patients with AL Amyloidosis....Pages 191-196
Front Matter....Pages 197-197
The Structure of Protein AA and its Correlation to the Tissue Distribution of Amyloid....Pages 199-203
Amino Acid Sequence Composition of AA Amyloid Fibrils in Cystic Fibrosis....Pages 205-209
Phylogenetic Analysis of Amyloid a Protein....Pages 211-216
Characterization of Serum Amyloid a (SAA) Protein in the Sheep....Pages 217-222
Structural Studies of SAA and AA from Horse and Cow....Pages 223-228
SAA Versus CRP Serum Levels in Different Inflammatory Conditions, Studied by Elisa Using Polyclonal Anti-AA and Monoclonal Anti-SAA Antibodies....Pages 229-233
Monoclonal Antibody to SAAL 1–3 Isomer Better Discriminant of the Acute Phase Reaction to Cancer and Monitor of Disease Progression than the Polyclonal Antibody to Human AA....Pages 235-240
Monoclonal Antibody Against Synthesized Short Peptides Corresponding to Human Amyloid a Protein....Pages 241-246
Front Matter....Pages 197-197
Diagnosis of AA-Amyloidosis Using Monoclonal Antibodies: Application to Paraffin and Ultrathin Sections as Well as to Urinary Sediments....Pages 247-252
Influence of Serum Amyloid A on Human Lecithin : Cholesterol Acyltransferase Activity....Pages 253-258
Structure and Variation in the Human Serum Amyloid A Gene Family....Pages 259-263
Serum Amyloid A: Characterization of Three cDNAS in One Individual and Complete Structure of their Corresponding Protein Products....Pages 265-269
Regulation of Human SAA Gene Expression....Pages 271-276
Localization of Amyloid SAA Gene Expression in Mouse Liver by in Situ Hybridization....Pages 277-282
Rat Liver and Lung Express Serum Amyloid A Related mRNAs....Pages 283-287
Identification of Cells Expressing SAA 3 mRNA by in Situ Hybridization....Pages 289-292
Diverse Gene Structure for Serum Amyloid a Protein in Wild Mice....Pages 293-297
Front Matter....Pages 299-299
Two New DNA-Based Tests for Mutations Causing Familial Amyloidotic Polyneuropathy....Pages 301-305
Epitope Mapping of TTR (Prealbumin) and TTR(Met 30 ) with Monoclonal Antibodies....Pages 307-310
Amyloid Fibril Formation by Polymerization of Abnormal Transthyretin....Pages 311-316
Demonstration of Transthyretin (Prealbumin) Variants in Italian Kindreds with Familial Amyloidotic Polyneuropathy....Pages 317-321
Abnormal Transthyretin in Familial Amyloidotic Polyneuropathy in Japan and Sweden....Pages 323-328
Elderly Asymptomatic Carriers and Late-Onset Cases of Familial Amyloidotic Polyneuropathy Detected by Radioimmunoassay....Pages 329-334
Studies on the Fate of Normal and Variant Prealbumin in the Circulation....Pages 335-341
Studies on Transthyretin Metabolism in the Nervous System....Pages 343-348
Alpha-Adrenergic Receptors in Familial Amyloidotic Polyneuropathy....Pages 349-354
DNA Tests for Four Prealbumin Mutations in Hereditary Amyloidosis....Pages 355-360
Prealbumin Gene Expression in Control Subjects and Individuals with Familial Amyloidotic Polyneuropathy....Pages 361-364
Front Matter....Pages 299-299
Diagnosis of Familial Amyloid Polyneuropathy by Recombinant DNA Techniques in Relation with Clinical Features....Pages 365-370
Haplotype Analisis of Familial Amyloidotic Polyneuropathy: an Evidence for Multiple Origins of the Val→met Mutation....Pages 371-376
DNA Polymorphisms Analysis in Families with Familial Amyloidotic Polyneuropathy (FAP) from Different Ethnic Origins....Pages 377-382
RFLP Analysis of Mutated Transthyretin in Vitreous Amyloidosis....Pages 383-386
Familial Amyloidotic Polyneuropathy in Sweden — RFLP Analysis in Patients and in Healthy Controls....Pages 387-392
A Potential Animal Model for Familial Amyloidotic Polyneuropathy Through Introduction of Human Mutant Transthyretin Gene Into Mice....Pages 393-398
Toward Establishment of an Animal Model for Familial Amyloidotic Polyneuropathy: Generation and Characterization of Transgenic Mice....Pages 399-404
Localization of Prealbumin mRNA in Fetal and Adult Mice....Pages 405-409
Front Matter....Pages 411-411
Is the Homozygous State for Hereditary Amyloid Neuropathy (HAN) — Type I (Portuguese, Andrade) Incompatible with Early Intrauterine Life?....Pages 413-418
Familial Amyloid Polyneuropathy: A Clinical Scale for the Evaluation of the Peripheral Neuropathy....Pages 419-423
Familial Amyloidotic Polyneuropathy: Screening of the Population at Risk in Portugal....Pages 425-428
Familial Amyloid Polyneuropathy (Portuguese Type): Study of Asymptomatic Carriers....Pages 429-434
Late-Onset Forms of Familial Amyloid Polyneuropathy (Portuguese Type): A Reappraisal....Pages 435-439
Genetic Study of Late-Onset in Hereditary Amyloid Neuropathy (HAN) — Type I (Portuguese, Andrade)....Pages 441-446
Genetic Expression of a Variant Prealbumin in Typical and Late-Onset Japanese Family with Familial Amyloidotic Polyneuropathy....Pages 447-451
Natural History of the ECG Abnormalities in FAP Portuguese Type: A Follow-Up Study with ECG, Holter Monitoring and Intracardiac Electrophysiological Study....Pages 453-457
Development of High-Grade Ventricular Arrhythmias in Familial Amyloid Polyneuropathy....Pages 459-464
Early Detection of Amyloid Heart Disease by Technetium-99M-Pyrophosphate Single-Photon Emission-Computed Tomography : A Study with Familial Amyloid Polyneuropathy....Pages 465-469
Impaired Left Ventricular Diastolic Properties in Patients with Familial Amyloid Polyneuropathy : A Study by Computerized M-Mode Echocardiography....Pages 471-473
Noninvasive Evaluation of Left Ventricular Systolic and Diastolic Time Intervals in Familial Amyloid Polyneuropathy....Pages 475-480
Front Matter....Pages 411-411
Molecular Analysis of a Variant Type of Familial Amyloidotic Polyneuropathy (FAP) Showing Cerebellar Ataxia and Pyramidal Tract Signs....Pages 481-486
Morphometric Study on Changes in Sural Nerves and Comparison with Clinical Manifestations in Familial Amyloidosis....Pages 487-491
Sural Nerve Biopsy in Familial Amyloidotic Polyneuropathy: A Morphological and Morphometric Polyneuropathy....Pages 493-498
Clinicopathological Studies on Nephropathy of Familial Amyloid Polyneuropathy in Japan....Pages 499-504
Pathology of Familial Amyloidotic Polyneuropathy Occurring in Kumamoto....Pages 505-510
Pathological Sutdies on Familial Amyloidosis....Pages 511-516
Front Matter....Pages 517-517
A Unique Protein that Shares a Common Epitope with Senile Plaque in Alzheimer’s Disease Brain....Pages 519-523
Preparation of a Monoclonal Antibody Against a Synthetic Brain Amyloid Beta Peptide(N1–10) and Distribution of an Immunoreactivity in Serum....Pages 525-530
Biochemical and Molecular Studies of Native and Synthetic B-Amyloid Protein in Alzheimer’s Disease....Pages 531-536
β-Amyloid cDNA Cloned from Alzheimer’s Disease Brain....Pages 537-541
α-1-Antichymotrypsin, a Serine Protease Inhibitor, is a Component of the Amyloid Deposits in Alzheimer’s Disease....Pages 543-548
Immunohistochemical Study of Alzheimer Disease Using Antibodies to Synthetic Amyloid and Fibronectin....Pages 549-553
Monoclonal Antibody AM34 Detects New Proteins Associated with Secondary Amyloidosis....Pages 555-560
Corpora Amylacea in Aging and Alzheimer’s Brain: Immunolocalization of Chondroitin Sulfate and Heparan Sulfate Proteoglycans....Pages 561-566
Ubiquitin: A Newly Identified Component of Paired Helical Filaments....Pages 567-572
Ultrastructure of Amyloid Fibrils in Alzheimer’s Disease and Down’s Syndrome....Pages 573-578
An Isolate of Families with Hereditary Cystatin C Amyloid Angiopathy and Cerebral Haemorrhage in the South of Iceland....Pages 579-584
Distribution of Cystatin C Amyloid Deposits in the Icelandic Patients with Hereditary Cystatin C Amyloid Angiopathy....Pages 585-590
Studies on the Cystatin C Gene in Patients with Hereditary Cystatin C Amyloid Angiopathy (HCCAA) with Cerebral Haemorrhage....Pages 591-596
Possibly “Familial” Cerebral Amyloid Angiopathy in Japan: Immunohistochemical Identification of Gamma-Trace....Pages 597-602
Front Matter....Pages 603-603
Beta-2 Microglobulin Amyloidosis....Pages 605-610
Chemical Analysis of Beta 2 -Microglobulin Derived Amyloid in Patients on Long-Term Hemodialysis....Pages 611-616
Coexistence of B 2 -Microglobulin-Derived Amyloid Deposits and Ectopic Calcification in the Heart of a Chronic Hemodialysis Patient....Pages 617-622
β 2 -Microglobulin Binding to Collagen : An Amyloidogenic Factor in Chronic Hemodialysis Patients....Pages 623-627
New Adsorbents for Extracorporeal Removal of β 2 -Microglobulin....Pages 629-634
Characterization of a Prealbumin Variant in Familial Amyloid Cardiomyopathy of Danish Origin....Pages 635-640
Senile Cardiovascular Amyloid: Lack of Evidence for Differences Between Amyloid Fibril Protein and Normal Transthyretin....Pages 641-645
Amyloid Fibril Protein in Finnish Hereditary Amyloidosis....Pages 647-652
Biochemical Characterization of Amyloid Protein in Primary Lichen Amyloidosis....Pages 653-656
Immunological Examination of Senile Amyloidosis of the Temporal Artery....Pages 657-659
Isolated Atrial Amyloid (IAA): A Cardiac Amyloid of Endocrine Origin....Pages 661-666
The Nature of the Amyloid in the Islets of Langerhans: A Novel Polypeptide Hormone?....Pages 667-671
Relationships of Islet Amyloid Polypeptide (IAPP) to Spontaneous Diabetes in Adult Cats....Pages 673-678
Serum Clearance Rate of Senile Amyloid Related Apolipoprotein A-II is Accelerated with Increasing Age in Senescence Accelerated Mouse (SAM)....Pages 679-683
AS SAM Amyloidosis is Present in Aging Mice of Many Strains, not Only in SAM....Pages 685-690
Immunohistochemical Studies of Age-Associated Amyloid Deposition in the Joint of Senescence-Accelerated Mouse (SAM)....Pages 691-694
Biochemical and Genetic Characterization of Murine Senile Amyloidosis....Pages 695-700
Front Matter....Pages 701-701
Possible Derivation of Cutaneous Amyloid from Degenerating Collagen Fibers: Ultrastructural, Immunohistological Studies Employing Anticollagen Antibodies....Pages 703-708
Immunohistochemical Staining Properties of Cutaneous Amyloidosis Using Anti-Keratin Monoclonal Antibodies....Pages 709-713
Reactivity of Immunoglobulins on Amyloid in Lichenoid and Macular Amyloidoses with Epidermal Keratin....Pages 715-720
Front Matter....Pages 701-701
Amyloid Deposition and Elastic Fiber in Cutaneous Amyloidosis....Pages 721-726
Amyloid in the Skin of Patients Undergoing Long-Term Hemodialysis....Pages 727-730
Histochemical and Ultrastructural Studies on the Pigment Abnormality in Cutaneous Amyloidosis....Pages 731-736
Hepatic Amyloidosis (AL): The Natural History in 80 Patients....Pages 737-742
Gastrointestinal Manifestations in Systemic Amyloidosis....Pages 743-748
Amyloid Localized to Tenosynovium at Carpal Tunnel Release: The Natural History of 124 Cases....Pages 749-754
Analysis of Paraproyein Deposition in the Kidney: Therapeutic Approach to Renal Amyloidosis....Pages 755-758
Immunohistochemical and Ultrastructural Studies of Amyloid Deposition in Squamous Cell Carcinoma of Uterine Cervix....Pages 759-764
An Autopsy Case of Recessive Dystrophic Epidermolysis Bullosa Complicating Secondary Systemic Amyloidosis....Pages 765-769
Systemic Amyloidosis Associated with Giant Lymph Node Hyperplasia....Pages 771-776
Amyloidosis Associated with Systemic Lupus Erythematosus....Pages 777-782
An Autopsied Case of Systemic Light Chain Deposition Disease (LCDD): The Relationship between LCDD and AL Amyloidosis....Pages 783-788
Immunohistochemical Classification of Amyloidosis and Immunohistochemistry of Fibrillar Nephropathy on Routinely Processed Plastic-Embedded Tissues....Pages 789-794
Histologic Characterization of Amyloidosis Based on Amyloid Proteins....Pages 795-799
The Subcutaneous Fat Aspirate: A Controlled and Blinded Evaluation of the Technique in the Diagnosis of Primary Amyloidosis (AL)....Pages 801-805
Three-Dimensional Analysis of Heart and Kidney in Primary Amyloidosis with Neural Involvement....Pages 807-812
Front Matter....Pages 813-813
DMSO Therapy Using Dermal Application to Patients with Systemic Amyloidosis....Pages 815-819
Systemic Amyloidosis: A Clinical Survey of 162 Cases....Pages 821-826
Natural History of Ogawa Village Type Familial Amyloid Polyneuropathy in Japan....Pages 827-832
Colchicine Analogues in Experimental Murine Amyloidogenesis....Pages 833-837
Front Matter....Pages 813-813
Evaluation of Serum Variant Prealbumin Levels, and its Behavior after Plasma Exchange for Familial Amyloidotic Polyneuropathy (Type 1)....Pages 839-844
Periodic Plasma Exchanges in the Treatment of Familial Amyloid Polyneuropathy: Preliminary Results....Pages 845-849
Treatment of Autonomic Dysfunction with L-Threo-3,4-Dihydroxyphenylserine in Patients with Familial Amyloidotic Polyneuropathy: A Multicenter Study....Pages 851-856
Treatment of Autonomic Disorders of Familial Amyloid Polyneuropathy with L-Threo-3,4-Dihydroxyphenyserine....Pages 857-861
Treatment of Orthostatic Hypotension in Familial Amyloidotic Polyneuropathy with L-Threo-3,4-Dihydroxyphenylserine....Pages 863-868
Insulin for Nausea in Familial Amyloid Polyneuropathy....Pages 869-874
Pacemaker Treatment in Familial Amyloid Polyneuropathy....Pages 875-877
Back Matter....Pages 879-885