Amino Acid Availability and Brain Function in Health and Disease

Front Matter....Pages I-XVIII
Front Matter....Pages 1-1
Nutritional & Metabolic Control of Brain Amino Acid Concentrations....Pages 3-12
Essential Nature of the “Dispensable” Amino Acids and Their Possible Influence on the Development and Function of the Brain, with a Note on the Question of Whether the Fetus Really Concentrates Amino Acids from the Mother’s Blood....Pages 13-19
The Importance of the Liver as a Regulator of Amino Acid Supply to the Brain....Pages 21-28
Bioavailability of Amino Acids and Amino Acid Precursors for Neurotransmitter Action: The Role of Hormones....Pages 29-37
Feeding, Stress, Exercise and the Supply of Amino Acids to the Brain....Pages 39-49
Back Matter....Pages 51-54
Front Matter....Pages 55-55
Regulation of Amino Acid Transport at the Blood-Brain Barrier....Pages 57-68
Enzymes of the Cerebrovascular Endothelium; Possible Relevance to the Interpretation of Precursor-Loading Experiments....Pages 69-79
Dynamics of the Cellular and Extracellular Compartment of Brain Amino Acids — Visions and Reality of the Dialysis Approach....Pages 81-90
Glial Cells as Metabolic Regulators of Neurons....Pages 91-100
Uptake and Release of Amino Acids from Synaptosomes....Pages 101-110
Back Matter....Pages 111-113
Front Matter....Pages 115-115
Pprocesses That Couple Amino Acid Availability to Neurotransmitter Synthesis and Release....Pages 117-136
Tryptophan Availability and Serotonin Synthesis in Brain....Pages 137-146
Disproportionate Amino Acid Diets and Anorexic Responses in Rats: The Role(s) of Limbic Brain Areas and Noradrenergic and Serotoninergic Systems....Pages 147-157
Effects of Tryptophan Administration on the Synthesis, Storage and Metabolism of Serotonin in the Hypothalamus of Normal and Raphe-Stimulated Rats....Pages 159-166
Amino Acid Availability and Control of Histaminergic Systems In the Brain....Pages 167-173
Back Matter....Pages 175-179
Front Matter....Pages 181-181
The Relationship of the Synthesis and Metabolism of Catecholamines to Brain Function....Pages 183-189
Precursor Availability and Function of Midbrain Dopaminergic Neurons....Pages 191-200
Modification of Synthesis, Release, and Function of Catecholaminergic Systems by Phenylalanine....Pages 201-206
Monoamines and Seizures in Genetically Epilepsy-Prone Rats: Inferences from Precursor Availability....Pages 207-214
Regulation of Neurotransmitter Amino Acid Fluxes by Excitatory Amino Acid Receptors in Different Neural Cell Types in Culture....Pages 215-224
Back Matter....Pages 225-236
Front Matter....Pages 237-237
Role of Amino Acids in Appetite Control in Man....Pages 239-248
Amino Acids in the Regulation of Food Intake and Selection....Pages 249-257
Control of Eating Behaviour by Amino Acid Supply....Pages 259-266
Tryptophan Availability in Humans: Effects on Mood and Behavior....Pages 267-274
Dietary Manipulation of Serotonin and Behaviour....Pages 275-283
Neuroendocrine Responses to Tryptophan as an Index of Brain Serotonin Function....Pages 285-290
Stress, Amino Acids and the Behavioural Effects of Drugs....Pages 291-298
Behavioral and Cognitive Effects of Altered Tryptophan and Tyrosine Supply....Pages 299-308
Back Matter....Pages 309-322
Front Matter....Pages 323-323
Excitatory Amino Acids in Epilepsy and in Acute and Chronic Neuronal Degenerative Disorders....Pages 325-332
Cerebral Capillary Amino Acid Uptake and Membrane Fluidity in Hepatic Encephalopathy....Pages 333-343
Amino Acid Therapy in Neurological Disease....Pages 345-353
Tryptophan and Tyrosine Ratios to Neutral Amino Acids in Depressed Patients in Regard to K m : Relation to Efficacy of Antidepressant Treatments....Pages 355-361
Serine Metabolism, beta-Carbolines and Psychoses....Pages 363-370
Brain Monoamine Oxidase B Activity and Amino Acid Precursor Treatment of Parkinson’s Disease, Depression and Epilepsy....Pages 371-379
Back Matter....Pages 381-389
Front Matter....Pages 391-391
Developmental Changes in Cerebral Amino Acids and Protein Metabolism....Pages 393-402
Blood-Brain Amino Acid Transport During Development....Pages 403-409
Nutrition and Selective Accumulation Processes Establish the Free Amino Acid Pool of Developing Chick Embryo Brain....Pages 411-420
Consequences of Experimental Modulations of Amino Acid Availability during Brain Development....Pages 421-429
Neurotransmitters and Early Embryogenesis....Pages 431-439
Role of Excitatory Amino Acids in the Development of Cerebellar Granule Neurones....Pages 441-448
Back Matter....Pages 465-468
Front Matter....Pages 391-391
Gamma-Aminobutyric Acid as a Neurotrophic Agent....Pages 449-456
Role of Taurine in Brain Development and Vision....Pages 457-464
Back Matter....Pages 465-468
Back Matter....Pages 469-489