Amine Oxidases: Function and Dysfunction: Proceedings of the 5th International Amine Oxidase Workshop, Galway, Ireland, August 22–25, 1992

Front Matter....Pages I-XII
Front Matter....Pages 1-1
Functional expression of C-terminally truncated human monoamine oxidase type A in Saccharomyces cerevisiae ....Pages 3-15
Kinetic properties of cloned human liver monoamine oxidase A....Pages 17-26
Identification of human monoamine oxidase (MAO) A and B gene promoters....Pages 27-33
Some problems associated with measuring monoamine oxidase activity in the presence of sodium azide....Pages 35-39
Some kinetic properties of guinea pig liver monoamine oxidase....Pages 41-45
Estimation of monoamine oxidase concentrations in soluble and membrane-bound preparations by inhibitor binding....Pages 47-53
Front Matter....Pages 55-55
Monoamine oxidase and catecholamine metabolism....Pages 57-67
Monoamine oxidase (MAO; E.C. 1.4.3.4) characteristics of platelets influenced by in vitro and in vivo ethanol on alcoholics and on control subjects....Pages 69-73
The effects of ethanol on rat brain monoamine oxidase activities....Pages 75-81
Species differences in changes of heart monoamine oxidase activities with age....Pages 83-87
Age-related changes on MAO in B1/C57 mouse tissues: a quantitative radioautographic study....Pages 89-94
The FAD dependent amine oxidases in relation to developmental state of enterocyte....Pages 95-99
Role of monoamine oxidase and cathecol-O-methyltransferase in the metabolism of renal dopamine....Pages 101-105
Comparison of the effect of reversible and irreversible MAO inhibitors on renal nerve activity in the anesthetized rat....Pages 107-113
Chronic administration of the antidepressant phenelzine and its N-acetyl analogue: effects on GABAergic function....Pages 115-122
Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A....Pages 123-125
Comparisons of the actions of high and low doses of the MAO inhibitor tranylcypromine on 5-HT 2 binding sites in rat cortex....Pages 127-134
Clorgyline effect on pineal melatonin biosynthesis in adrenalectomized rats pretreated with 6-hydroxydopamine....Pages 135-139
Synergistic sedative effect of selective MAO-A, but not MAO-B, inhibitors and melatonin in frogs....Pages 141-144
Clorgyline effect on pineal melatonin biosynthesis in roman high- and low-avoidance rats....Pages 145-148
Front Matter....Pages 55-55
Reboxetine prevents the tranylcypromine-induced increase in tyramine levels in rat heart....Pages 149-153
Monoamine oxidase inhibitors: effects on tryptophan concentrations in rat brain....Pages 155-163
Front Matter....Pages 165-165
Behaviour of (-)-deprenyl and its analogues....Pages 167-175
Is selegiline neuroprotective in Parkinson’s disease?....Pages 177-188
Suppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuroprotective mechanism in dopaminergic neurotoxicity....Pages 189-196
Novel toxins and Parkinson’s disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin....Pages 197-205
Amphetamine-metabolites of deprenyl involved in protection against neurotoxicity induced by MPTP and 2′-methyl-MPTP....Pages 207-219
Is brain superoxide dismutase activity increased following chronic treatment with 1-deprenyl?....Pages 221-229
Lifespan of immunosuppressed NMRI-mice is increased by deprenyl....Pages 231-236
Double blind cross over trial with deprenyl in amyotrophic lateral sclerosis....Pages 237-241
Monoamine oxidase-B in motor cortex and spinal cord in amyotrophic lateral sclerosis studied by quantitative autoradiography....Pages 243-248
The effect of 6-months l-deprenyl administration on pineal MAO-A and MAO-B activity and on the content of melatonin and related indoles in aged female Fisher 344N rats....Pages 249-252
Reactive gliosis and monoamine oxidase B....Pages 253-258
Monoamine oxidase inhibitors, cognitive functions and neurodegenerative diseases....Pages 259-266
Front Matter....Pages 267-267
Can our knowledge of monoamine oxidase (MAO) help in the design of better MAO inhibitors?....Pages 269-279
Kinetic behaviour of some acetylenic indolalkylamine derivatives and their corresponding parent amines....Pages 281-285
Acetylenic and allenic derivatives of 2-(5-methoxy-l-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B....Pages 287-290
Interactions between substituted tryptamine analogues, MAO inhibitors and cytochrome P-450....Pages 291-293
Inhibition of monoamine oxidase by clorgyline analogues....Pages 295-305
Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues....Pages 307-311
Front Matter....Pages 267-267
Experimental and theoretical study of reversible monoamine oxidase inhibitors: structural approach of the active site of the enzyme....Pages 313-319
Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: preclinical and clinical findings....Pages 321-325
Food-derived hetero-cyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole and related amines, as inhibitors of monoamine metabolism....Pages 327-333
Chronopharmacological study of moclobemide effect on the rat pineal melatonin biosynthesis....Pages 335-337
Biochemical pharmacology of befloxatone (MD370503), a new potent reversible MAO-A inhibitor....Pages 339-347
Effects of befloxatone, a new potent reversible MAO-A inhibitor, on cortex and striatum monoamines in freely moving rats....Pages 349-355
The effects of brofaromine, a reversible MAO-A inhibitor, on extracellular serotonin in the raphe nuclei and frontal cortex of freely moving rats....Pages 357-363
In vivo effects of the monoamine oxidase inhibitors Ro 41-1049 and Ro 19-6327 on the production and fate of renal dopamine....Pages 365-370
Pharmacodynamics of MDL 72974A: absence of effect on the pressor response to oral tyramine....Pages 371-375
The acute effect of the bioprecursor of the selective brain MAO-A inhibitor, MDL 72392, on rat pineal melatonin biosynthesis....Pages 377-379
Chronic effect of the irreversible and reversible selective MAO-A inhibitors on rat pineal melatonin biosynthesis....Pages 381-384
Front Matter....Pages 385-385
Properties of mammalian tissue-bound semicarbazide-sensitive amine oxidase: possible clues to its physiological function?....Pages 387-396
Deamination of aliphatic amines by type B monoamine oxidase and semicarbazide-sensitive amine oxidase; pharmacological implications....Pages 397-406
Haloallylamine inhibitors of MAO and SSAO and their therapeutic potential....Pages 407-414
Several aspects on the amine oxidation by semicarbazide-sensitive amine oxidase (SSAO) from bovine lung....Pages 415-420
Semicarbazide-sensitive amine oxidase activity of guinea pig dorsal skin....Pages 421-426
Semicarbazide-sensitive amine oxidases in sheep plasma: interactions with some substrates and inhibitors....Pages 427-432
Location of the active site of rat vascular semicarbazide-sensitive amine oxidase....Pages 433-437
The ex vivo effects of procarbazine and methylhydrazine on some rat amine oxidase activities....Pages 439-443
Histaminase activity of mesenteric artery of the rat....Pages 445-448
Back Matter....Pages 449-457