Alzheimer: 100 years and beyond

Front Matter....Pages I-XXXIII
Front Matter....Pages 1-1
Concerning a unique disease of the cerebral cortex....Pages 3-11
The history of Alois Alzheimer’s first case Auguste D.....Pages 13-34
Alois Alzheimer and the beginnings of research into Alzheimer’s disease....Pages 37-49
Alois Alzheimer and the myth of the pioneer....Pages 51-55
Front Matter....Pages 57-57
Alzheimer’s Disease at mid-Century (1927–1977) and a little more....Pages 59-61
A chapter in the development on Alzheimer’s disease research....Pages 63-86
Front Matter....Pages 87-87
Anatomical changes underlying dementia in Alzheimer’s disease....Pages 89-94
Staging of cortical neurofibrillary inclusions of the Alzheimer’s type....Pages 97-106
Of stains and brains: a brief account of how microscopic and clinical observations contributed to the understanding of Alzheimer’s disease....Pages 109-113
Presenile forms of Alzheimer’s disease in 2006....Pages 115-119
Front Matter....Pages 121-121
The cholinergic deficit in Alzheimer’s disease....Pages 123-125
Acetylcholine in AD: Expectations meet reality....Pages 127-132
Front Matter....Pages 133-133
The Discovery of β Amyloid....Pages 135-140
Pathways to the discovery of the neuronal origin and proteolytic biogenesis of Aβ amyloid of Alzheimer’s disease....Pages 143-149
The Amyloid Hypothesis: history and alternatives....Pages 151-154
Segregation of a missense mutation in the amyloid β-protein precursor gene with familial Alzheimer’s disease....Pages 157-161
From the amyloid β protein (A4) to isolation of the first Alzheimer’s disease gene: amyloid β (A4) precursor protein (APP)....Pages 163-169
Commentary on “Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice”....Pages 171-172
Vision for the future....Pages 175-186
 PS1 , PS2 , and APP mutations that cause Alzheimer’s disease increase Aβ42....Pages 189-195
Front Matter....Pages 133-133
Amyloid precursor protein, Alzheimer’s disease, and Down’s syndrome....Pages 197-199
Catabolism of amyloid β peptide and pathogenesis of sporadic Alzheimer’s disease: towards understanding the underlying mechanisms....Pages 201-206
Synaptic activity, amyloid-β and Alzheimer’s disease....Pages 209-213
Molecular pathogenesis of Alzheimer’s disease in human peripheral cells: platelets show it all!....Pages 215-218
The neuronal origin hypothesis of cerebral amyloid angiopathy....Pages 221-223
A neuropathologist and Alzheimer genetics....Pages 225-230
Genetics, molecular biology, and animal modeling of Alzheimer’s disease....Pages 231-234
The genetic Alzheimer-frontotemporal dementia spectrum....Pages 237-240
Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. The role of amyloid in dementia and stroke....Pages 243-246
Physiological generation of Amyloid β-peptide and its Consequences for Alzheimer’s disease research....Pages 249-253
Activation of α-secretase as an approach for treatment of Alzheimer’s disease....Pages 255-259
Challenges to the enigma of γ-secretase and to Alzheimer’s disease....Pages 261-263
Targeting γ-Secretase for Alzheimer’s Disease....Pages 265-268
The Presenilin/gamma-secretase complex and its potential as a drug target in Alzheimer’s Disease....Pages 271-274
Identification of β-secretase....Pages 277-280
Front Matter....Pages 281-281
Apolipoprotein E and Alzheimer’s disease: A brief retrospective....Pages 283-286
Apolipoprotein E4: From synaptic remodeling to genetic risk factor in both familial and sporadic Alzheimer’s disease....Pages 289-294
Front Matter....Pages 295-295
The Alzheimer tangle — 100 years on.....Pages 297-304
Immunological demonstration of tau protein in neurofibrillary tangles....Pages 307-312
Bulk isolation of neurofibrillary tangles and discoveries of tau and its abnormal hyperphosphorylation....Pages 315-322
Front Matter....Pages 295-295
The natural and molecular history of Alzheimer’s disease: Tau is part of the story....Pages 325-331
Tau focused drug discovery for Alzheimer’s disease and related Neurodegenerative Tauopathies....Pages 333-336
Ubiquitin is a component of paired helical filaments in Alzheimer’s disease....Pages 339-343
Influence of tau on neuronal traffic mechanisms....Pages 345-353
The Search for structure of tau and paired helical filaments....Pages 355-364
Front Matter....Pages 365-365
The Changing landscape of Alzheimer’s disease: From Insoluble to Soluble and from Pathogen to Protector....Pages 367-369
Molecular and cellular pathways towards and away from Alzheimer’s disease....Pages 371-375
Front Matter....Pages 377-377
Paquid: an integrated, multidisciplinary, population-based approach to normal and pathological cerebral aging....Pages 379-382
Front Matter....Pages 383-383
Hippocampal imaging in the early diagnosis of AD, 1988 to 2006....Pages 385-390
Detecting Early-Stage Alzheimer’s Disease in MCI and PreMCI: The value of informants....Pages 393-397
Imaging the pathology of Alzheimer’s disease: Building on a century-Old blueprint....Pages 399-403
Front Matter....Pages 405-405
How do we test drugs?....Pages 407-410
Inflammation and the lesions of Alzheimer’s disease....Pages 413-416
Aβ immunotherapy prevents and Reverses Alzheimer’s disease neuropathology....Pages 419-422
Immunotherapy of Alzheimer’s disease....Pages 425-428
“Magic” bullets, shotguns or cocktails to treat or prevent Alzheimer’s disease?....Pages 431-433
The seventh age of man: Solving senility....Pages 435-440
Front Matter....Pages 441-441
Fondation Ipsen and Alzheimer’s disease: a 20-year relationship....Pages 443-454
Alzheimer Research Forum: A Knowledge Base and e-Community for AD Research....Pages 457-463
Back Matter....Pages 465-543