Aging of the Brain and Alzheimer's Disease

Content: 
Recent volumes in Progress in Brain Research
Page iv

Edited by
Page iii

Copyright page
Page iv

List of Contributors
Pages v-vii

Preface
Pages ix-x
D.F. Swaab, E. Fliers, M. Mirmiran, W.A. Van Gool, F. Van Haaren

Acknowledgements
Page xi
D.F. Swaab, E. Fliers, M. Mirmiran, W.A. Van Gool, F. Van Haaren

Chapter 1 Clinical approach to dementia Original Research Article
Pages 3-13
H. Van Crevel

Chapter 2 Cognitive, emotional and behavioral dysfunctions in aging and dementia Original Research Article
Pages 15-39
J. Jolles

Chapter 3 Interrelations among the lesions of normal and abnormal aging of the brain Original Research Article
Pages 41-48
R.D. Terry

Chapter 4 Age-related changes in Down syndrome brain and the cellular pathology of Alzheimer disease Original Research Article
Pages 49-67
R.S. Williams, S. Matthysse

Chapter 5 Measurement and imaging of cerebral function in ageing and dementia Original Research Article
Pages 69-85
R.S.J. Frackowiak

Chapter 6 The endogenous components of the event-related potential — a diagnostic tool? Original Research Article
Pages 87-102
E. Donchin, G.A. Miller, L.A. Farwell

Chapter 7 The current status of the cortical cholinergic system in Alzheimer\'s disease and Parkinson\'s disease Original Research Article
Pages 105-132
J.M. Candy, E.K. Perry, R.H. Perry, J.A. Court, A.E. Oakley, J.A. Edwardson

Chapter 8 Monoamines and myelin components in aging and dementia disorders Original Research Article
Pages 133-140
C.G. Gottfries

Chapter 9 Neuropeptide changes in aging and Alzheimer\'s disease Original Research Article
Pages 141-152
E. Fliers, D.F. Swaab

Chapter 10 Cortical neurochemistry in Alzheimer-type dementia Original Research Article
Pages 153-169
A.J. Cross, T.J. Crow, T.J. Peters

Chapter 11 Lipofuscin: characteristics and significance Original Research Article
Pages 171-183
R.S. Sohal, L.S. Wolfe

Chapter 12 Ratio of pyramidal cells versus non-pyramidal cells in the human frontal isocortex and changes in ratio with ageing and Alzheimer\'s disease Original Research Article
Pages 185-212
H. Braak, E. Braak

Chapter 13 Cation shifts and excitotoxins in Alzheimer and Huntington disease and experimental brain damage Original Research Article
Pages 213-226
J. Korf, J.-B.P. Gramsbergen, G.H.M. Prenen, K.G. Go

Chapter 14 Dendritic proliferation in the aging brain as a compensatory repair mechanism Original Research Article
Pages 227-237
P.D. Coleman, D.G. Flood

Chapter 15 Neuronal cell membranes and brain aging Original Research Article
Pages 239-254
A.B. Oestreicher, P.N.E. De Graan, W.H. Gispen

Chapter 16 Aging and circadian rhythms Original Research Article
Pages 255-277
W.A. Van Gool, M. Mirmiran

Chapter 17 Neuronal cytoskeleton in aging and dementia Original Research Article
Pages 279-288
K. Iqbal, I. Grundke-Iqbal, H.M. Wisniewski

Chapter 18 DNA damage, DNA repair and the genetic basis of Alzheimer\'s disease Original Research Article
Pages 291-301
C. Kidson, P. Chen

Chapter 19 Transcriptional and translational regulatory mechanisms during normal aging of the mammalian brain and in Alzheimer\'s disease Original Research Article
Pages 303-320
C.A. Marotta, R.E. Majocha, J.F. Coughlin, H.J. Manz, P. Davies, M. Ventosa-Michelman, W.-G. Chou, S.B. Zain, E.M. Sajdel-Sulkowska

Chapter 20 Cell-specific pathology in neural systems of the temporal lobe in Alzheimer\'s disease Original Research Article
Pages 321-335
G.W. Van Hoesen, B.T. Hyman, A.R. Damasio

Chapter 21 The old animal as a model in research on brain aging and Alzheimer\'s disease/senile dementia of the Alzheimer type Original Research Article
Pages 337-343
C.F. Hollander, J. Mos

Chapter 22 Behavioral and biochemical effects of nucleus basalis magnocellularis lesions: implications and possible relevance to understanding or treating Alzheimer\'s disease Original Research Article
Pages 345-361
R.T. Bartus, C. Flicker, R.L. Dean, S. Fisher, M. Pontecorvo, J. Figueiredo

Chapter 23 Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons Original Research Article
Pages 363-389
M.V. Sofroniew, R.C.A. Pearson, O. Isacson, A. Björklund

Chapter 24 Scrapie and its association with ‘amyloid-like’ fibrils and glycoproteins encoded by cellular genes: an animal model for human dementia Original Research Article
Pages 391-398
J. Goudsmit, F.W. Van der Waals

Chapter 25 Aluminum: a role in degenerative brain disease associated with neurofibrillary degeneration Original Research Article
Pages 399-410
D.R. Crapper McLachlan, M.F.A. Van Berkum

Chapter 26 Clinical strategies in the treatment of Alzheimer\'s disease Original Research Article
Pages 413-427
D.F. Swaab, E. Fliers

Chapter 27 Neuropeptides and the treatment of cognitive deficits in aging and dementia Original Research Article
Pages 429-441
J. Jolles

Chapter 28 Environmental influences on brain and behavior in aging and Alzheimer\'s disease Original Research Article
Pages 443-459
M. Mirmiran, W.A. Van Gool, F. Van Haaren, C.E. Polak

Chapter 29 Possible dietary strategies to reduce cognitive deficits in old age Original Research Article
Pages 461-471
H.R. Lieberman, T.M. Abou-Nader

Chapter 30 The striatal dopaminergic system as a model for modulation of altered neurotransmitter action during aging: effects of dietary and neuroendocrine manipulations Original Research Article
Pages 473-484
G.S. Roth, J.M. Henry, J.A. Joseph

Chapter 31 Muscarinic cholinergic agonists: pharmacological and clinical perspectives Original Research Article
Pages 485-498
J.M. Palacios, R. Spiegel

Chapter 32 Transplantation of basal forebrain cholinergic neurons in the aged rat brain Original Research Article
Pages 499-512
A. Björklund, F.H. Gage

Subject Index
Pages 513-525