Adverse Drug Reactions

Front Matter....Pages 1-9
Front Matter....Pages 1-1
Drug-Induced Liver Injury....Pages 3-27
Drug Hypersensitivity Reactions Involving Skin....Pages 29-55
Adverse Drug Reactions Affecting Blood Cells....Pages 57-76
Molecular Mechanisms of Adverse Drug Reactions in Cardiac Tissue....Pages 77-109
Mechanisms of Drug-Induced Nephrotoxicity....Pages 111-130
Receptor- and Reactive Intermediate-Mediated Mechanisms of Teratogenesis....Pages 131-162
Front Matter....Pages 164-164
Role of Reactive Metabolites in Drug-Induced Hepatotoxicity....Pages 165-194
The Role of Cytokines in the Mechanism of Adverse Drug Reactions....Pages 195-231
The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms of Regulation and Role in Protection Against Drug-Induced Toxicity....Pages 233-266
Signal Transduction Pathways Involved in Drug-Induced Liver Injury....Pages 267-310
Mitochondrial Involvement in Drug-Induced Liver Injury....Pages 311-365
Front Matter....Pages 368-368
Mechanisms of Acetaminophen-Induced Liver Necrosis....Pages 369-405
Drug-Induced Liver Injury in Humans: The Case of Ximelagatran....Pages 407-418
Troglitazone....Pages 419-435
Nevirapine Hypersensitivity....Pages 437-451
Mechanisms of Adverse Drug Reactions to Biologics....Pages 453-474
Front Matter....Pages 476-476
Pharmacogenetics of Idiosyncratic Adverse Drug Reactions....Pages 477-491
The Danger Hypothesis Applied to Idiosyncratic Drug Reactions....Pages 493-509
Approaches for Minimizing Metabolic Activation of New Drug Candidates in Drug Discovery....Pages 511-544
Back Matter....Pages 1-12