Advances in TNF Family Research: Proceedings of the 12th International TNF Conference, 2009

Front Matter....Pages i-xxxvi
Front Matter....Pages 1-1
Workshop Summary: Roles of the TNF Family in Normal Development and Cancer ....Pages 3-4
TNF Conference 2009: Beyond Bones – RANKL/RANK in the Immune System....Pages 5-22
The Edar Subfamily in Hair and Exocrine Gland Development....Pages 23-33
High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculature....Pages 35-44
Eiger and Wengen: The Drosophila Orthologs of TNF/TNFR....Pages 45-50
Front Matter....Pages 51-51
Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs ....Pages 53-61
TRAF2 and Cellular IAPs: A Critical Link in TNFR Family Signaling....Pages 63-78
New Perspectives in TNF-R1-Induced NF- κ B Signaling....Pages 79-88
Structural Studies of NEMO and TRAF6: Implications in NF-κB Activation....Pages 89-91
Front Matter....Pages 93-93
Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF- κ B Precursor....Pages 95-106
Selective Binding of Linear Ubiquitin Chains to NEMO in NF-kappaB Activation....Pages 107-114
The Linear Ubiquitin Chain Assembly Complex (LUBAC) Forms Part of the TNF-R1 Signalling Complex and Is Required for Effective TNF-Induced Gene Induction and Prevents TNF-Induced Apoptosis....Pages 115-126
Temporal Control of TNFα Signaling by Miz1....Pages 127-128
Front Matter....Pages 129-129
Large-Scale RNAi Screens to Dissect TNF and NF- κ B Signaling Pathways....Pages 131-139
Pathogenic Role of IL-6 Combined with TNF-α or IL-1 in the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases....Pages 141-150
Understanding Life and Death at CD95....Pages 151-161
Unique Personalities Within the NF- κ B Family: Distinct Functions for p65 and RelB in the Osteoclast....Pages 163-167
Front Matter....Pages 169-169
Workshop Summary: Functions of the TNF Family in Infectious Disease....Pages 171-175
Role of 4-1BBL and TRAF1 in the CD8 T Cell Response to Influenza Virus and HIV....Pages 177-186
Roles of Soluble and Membrane TNF and Related Ligands in Mycobacterial Infections: Effects of Selective and Non-selective TNF Inhibitors During Infection....Pages 187-201
Front Matter....Pages 169-169
Poxviral TNFRs: Properties and Role in Viral Pathogenesis....Pages 203-210
Heme Sensitization to TNF-Mediated Programmed Cell Death....Pages 211-219
TNF-α and TNFR in Chagas Disease: From Protective Immunity to Pathogenesis of Chronic Cardiomyopathy....Pages 221-230
Lymphotoxin’s Link to Carcinogenesis: Friend or Foe? From Lymphoid Neogenesis to Hepatocellular Carcinoma and Prostate Cancer....Pages 231-249
Front Matter....Pages 251-251
Anti-inflammatory Functions of Caspase-8....Pages 253-260
Endogenous Ligand-Induced Activation of TLR4 in Pre-metastatic Phase Is Both Downstream and Upstream of TNF Signaling....Pages 261-268
Front Matter....Pages 269-269
Introductory Words About TL1A/DR3....Pages 271-274
Introductory Words About TWEAK/Fn14....Pages 275-277
Insights into TL1A and IBD Pathogenesis....Pages 279-288
The Role of TNFRSF25:TNFSF15 in Disease… and Health?....Pages 289-298
Identification of New Candidates as Mucosal Vaccine Adjuvant in TNF Family Cytokines....Pages 299-304
The TWEAK/Fn14 Pathway in Tissue Remodeling: For Better or for Worse....Pages 305-322
TWEAK and the Kidney: the Dual Role of a Multifunctional Cytokine....Pages 323-335
TWEAK and TNF Regulation of Sclerostin: A Novel Pathway for the Regulation of Bone Remodelling....Pages 337-348
Front Matter....Pages 349-349
Workshop Summary: Control of Lymphocyte Function and Repertoire by the TNF Superfamily....Pages 351-352
The Canonical and Unconventional Ligands of the Herpesvirus Entry Mediator....Pages 353-362
The Lymphotoxin Pathway as a Novel Regulator of Dendritic Cell Function....Pages 363-374
Involvement of the Cytokine Receptor CD137 in Murine Hematopoiesis....Pages 375-382
LTBR-Pathway in Sjogren’s Syndrome: CXCL13 Levels and B-cell-Enriched Ectopic Lymphoid Aggregates in NOD Mouse Lacrimal Glands Are Dependent on LTBR....Pages 383-390
MEK Kinase 1: Kinase Domain Deficiency in Mice Reveals a Role in Orchestrating the Thymus-Dependent Immunity and TNFR Family Signaling....Pages 391-397
Front Matter....Pages 399-399
Introduction to the Session “Mechanisms of Pathological and Therapeutic Effects of the TNF Family”....Pages 401-402
Mechanisms Regulating TNF-Driven Gut and Joint Inflammation....Pages 403-408
Lessons from Anti-TNF Biologics: Infliximab Failure in a TRAPS Family with the T50M Mutation in TNFRSF1A ....Pages 409-419
Modalities of Experimental TNF Blockade In Vivo: Mouse Models....Pages 421-431
Tumor Necrosis Factor-α Signaling via TNFR1/p55 Is Deleterious Whereas TNFR2/p75 Signaling Is Protective in Adult Infarct Myocardium....Pages 433-448
TNF-α Regulation of CD38 Expression in Human Airway Smooth Muscle: Role of MAP Kinases and NF-κB....Pages 449-459
Functional Consequences of Disease-Associated Mutations in TNFR1 Elucidated by Transcriptome Analysis....Pages 461-470
Tumor Necrosis Factor-α and Kidney Function: Experimental Findings in Mice....Pages 471-480
Strategies to Inhibit the Toxicity of Systemic TNF Treatment....Pages 481-484
Front Matter....Pages 485-485
Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family....Pages 487-491
Anti-inflammatory Effects of a Novel TNFR1-Selective Antagonistic TNF Mutant on Established Murine Collagen-Induced Arthritis....Pages 493-500
A Proliferation-Inducing Ligand (APRIL): The Development of Antagonistic Agents as Potential Therapeutics and Deciphering the Role of Heparan Sulphate Proteoglycans (HSPGs) in APRIL Signalling....Pages 501-506
Genetic Engineering of Death Ligands for Improvement of Therapeutic Activity....Pages 507-519
Computational Design of TNF Ligand-Based Protein Therapeutics....Pages 521-534
Front Matter....Pages 535-535
Workshop Summary: Roles of the TNF Family in Neuronal Development, Function and Pathology....Pages 537-538
TNF: A Key Neuroinflammatory Mediator of Neurotoxicity and Neurodegeneration in Models of Parkinson’s Disease....Pages 539-540
The Contribution of TNFα to Synaptic Plasticity and Nervous System Function....Pages 541-557
Intracellular and Intercellular Cross Talk Between NGF and TNF....Pages 559-565
TNFR2 – Target for Therapeutics Against Neurodegenerative Diseases?....Pages 567-573
A Role for Neuronal NF-κB in Suppressing Neuroinflammation and Promoting Neuroprotection in the CNS....Pages 575-581
Front Matter....Pages 583-583
Workshop Summary: Cell Death Mechanisms Controlled by the TNF Family....Pages 585-588
A RNA Interference Screen Identifies RIP3 as an Essential Inducer of TNF-Induced Programmed Necrosis....Pages 589-593
The Extracellular Matrix Protein CCN1 Dictates TNFα and FasL Cytotoxicity In Vivo....Pages 595-603
Compartmentalization of TNF-Receptor 1 Signaling: TNF-R1-Associated Caspase-8 Mediates Activation of Acid Sphingomyelinase in Late Endosomes....Pages 605-616
TNF/TNF Receptor 1-Mediated Apoptosis in Hepatocytes....Pages 617-624
Regulation of Cell Death by c-FLIP Phosphorylation....Pages 625-630
Back Matter....Pages 631-844