Advances in statistical methods for the health sciences : applications to cancer and AIDS studies, genome sequence analysis, and survival analysis

Front Matter....Pages i-xli
Front Matter....Pages 1-1
Systematic Review of Multiple Studies of Prognosis: The Feasibility of Obtaining Individual Patient Data....Pages 3-18
On Statistical Approaches for the Multivariable Analysis of Prognostic Marker Studies....Pages 19-38
Where Next for Evidence Synthesis of Prognostic Marker Studies? Improving the Quality and Reporting of Primary Studies to Facilitate Clinically Relevant Evidence-Based Results....Pages 39-58
Front Matter....Pages 59-59
Sentinel Event Methods for Monitoring Unanticipated Adverse Events....Pages 61-74
Spontaneous Reporting System Modelling for the Evaluation of Automatic Signal Generation Methods in Pharmacovigilance....Pages 75-92
Front Matter....Pages 93-93
Latent Covariates in Generalized Linear Models: A Rasch Model Approach....Pages 95-108
Sequential Analysis of Quality of Life Measurements with the Mixed Partial Credit Model....Pages 109-125
A Parametric Degradation Model Used in Reliability, Survival Analysis, and Quality of Life....Pages 127-138
Agreement Between Two Ratings with Different Ordinal Scales....Pages 139-148
Front Matter....Pages 149-149
The Role of Correlated Frailty Models in Studies of Human Health, Ageing, and Longevity....Pages 151-166
Prognostic Factors and Prediction of Residual Survival for Hospitalized Elderly Patients....Pages 167-178
New Models and Methods for Survival Analysis of Experimental Data....Pages 179-194
Uniform Consistency for Conditional Lifetime Distribution Estimators Under Random Right-Censorship....Pages 195-209
Sequential Estimation for the Semiparametric Additive Hazard Model....Pages 211-223
Variance Estimation of a Survival Function with Doubly Censored Failure Time Data....Pages 225-235
Front Matter....Pages 237-237
Statistical Models and Artificial Neural Networks: Supervised Classification and Prediction Via Soft Trees....Pages 239-261
Multilevel Clustering for Large Databases....Pages 263-274
Neural Networks: An Application for Predicting Smear Negative Pulmonary Tuberculosis....Pages 275-287
Assessing Drug Resistance in HIV Infection Using Viral Load Using Segmented Regression....Pages 289-304
Assessment of Treatment Effects on HIV Pathogenesis Under Treatment By State Space Models....Pages 305-319
Front Matter....Pages 321-321
Safety Assessment Versus Efficacy Assessment....Pages 323-334
Cancer Clinical Trials with Efficacy and Toxicity Endpoints: A Simulation Study to Compare Two Nonparametric Methods....Pages 335-348
Safety Assessment in Pilot Studies When Zero Events Are Observed....Pages 349-358
Front Matter....Pages 359-359
An Assessment of Up-and-Down Designs and Associated Estimators in Phase I Trials....Pages 361-386
Design of Multicentre Clinical Trials with Random Enrolment....Pages 387-400
Statistical Methods for Combining Clinical Trial Phases II And III....Pages 401-417
SCPRT: A Sequential Procedure That Gives Another Reason to Stop Clinical Trials Early....Pages 419-434
Front Matter....Pages 435-435
Seasonality Assessment for Biosurveillance Systems....Pages 437-450
Comparison of Three Convolution Prior Spatial Models for Cancer Incidence....Pages 451-466
Longitudinal Analysis of Short-Term Bronchiolitis Air Pollution Association Using Semiparametric Models....Pages 467-487
Front Matter....Pages 489-489
Are There Correlated Genomic Substitutions?....Pages 491-515
Front Matter....Pages 517-517
Swiss Federal Veterinary Office Risk Assessments: Advantages and Limitations of The Qualitative Method....Pages 519-526
Qualitative Risk Analysis in Animal Health: A Methodological Example....Pages 527-537
Back Matter....Pages 539-540