Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

Front Matter....Pages i-xxi
Phosphorylation and Activation of 5-Lipoxygenase by P38 Kinase-Activated MAPKAP Kinases....Pages 1-7
5-Lipoxygenase and the Nucleus: Where, When, How, and Why?....Pages 9-15
Calcium Binding Site of 5-Lipoxygenase....Pages 17-20
Regulation of Cellular 5-Lipoxygenase Activity by Glutathione Peroxidases....Pages 21-23
Novel Aspects Related to Biosynthesis and Biological Actions of Hepoxilins: Interrelationship with Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx)....Pages 25-29
Transcriptional Regulation of the Human Leukotriene C 4 Synthase Promoter....Pages 31-36
Localization and Translocation of Enzymes Involved in Leukotriene Biosynthesis....Pages 37-40
Regulation of COX-2 Expression in Fibroblasts, Osteoblasts, Mast Cells, and Macrophages....Pages 41-47
Antimicroinflammatory Lipid Signals from Vascular Cyclooxygenase-2: A Novel Mechanism for NSAID and N-3 PUFA Therapeutic Actions....Pages 49-55
Substrate Interactions in the Cyclooxygenase-1 Active Site....Pages 57-64
Mutation of the Human Prostacyclin Synthase Gene....Pages 65-68
Structure and Function of Two Distinct Types of Prostaglandin D Synthase....Pages 69-72
Roles of Prostaglandin F Synthase....Pages 73-76
Differential Effects of Nitric Oxide on Cyclooxygenase 1 and 2 Activities in Cultured Cells....Pages 77-80
On the Functional Diversity of Secreted Phospholipases A 2 : Cloning of Novel Mammalian Enzymes and HIV-1 Antiviral Properties....Pages 81-84
Regulation of Cytosolic Phospholipase A 2 by Phosphorylation....Pages 85-88
Synthesis and Function of 20-Hydroxyeicosatetraenoic Acid in the Kidney....Pages 89-97
Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP 2 Receptor Knockout Mice....Pages 99-101
Induction of Prostaglandin I 2 Receptor in Murine Osteoblastic Cell....Pages 103-106
BLT2, a Second Leukotriene B 4 Receptor....Pages 107-110
Upregulation of Cysteinyl-Leukotriene 1 Receptor Expression by Interleukin-5 in Human Leukocytes....Pages 111-113
Physiological and Pathophysiological Roles of Prostanoids; Lessons from Receptor-Knockout Mice for Clinical Applications....Pages 115-120
Multiple G-Protein Coupling of Chimeric Prostacyclin/Prostaglandin D2 Receptors....Pages 121-123
An Unusual Nicotinic Acetylcholine Receptor Activates the 8-Lipoxygenase Pathway in Aplysia Neurons....Pages 125-128
Neutrophil-Endothelial Cell Interaction: A Multidirectional Cross-Talk in Leukotriene Generation....Pages 129-133
Cyclooxygenase in the Lamb Ductus Arteriosus: Developmental Changes and Upregulation....Pages 135-137
Co-Localization of Prostacyclin (PGI2)-Synthase and Caveolin-1 in Endothelial Cells Underscores New Roles of PGI2 in Angiogenesis....Pages 139-142
Leukotriene C 4 Synthase Gene Polymorphism in Severe Asthma....Pages 143-148
Anti-Inflammatory Levels of Aspirin and Salicylate Inhibit Integrin-Dependent Human Neutrophil Aggregation and PMN Influx in COX 2- and NFkB (P105)-Knockout Mice....Pages 149-154
Antipyretic Action of Acetaminophen: Inhibition of the Cyclooxygenase Activity of Endothelial Cells Treated with IL-1....Pages 155-158
Leukotriene-Mediated Alteration of Endothelial Barrier Function....Pages 159-161
GI and Cardiovascular Profiles of New NSAIDs: Selective COX-2 Inhibitors and NO-NSAIDs....Pages 163-169
NO-Releasing NSAIDs Modulate Cytokine Secretion....Pages 171-178
Potent Inhibitory Efects of a NO-NSAID (Flurbiprofen Nitroxybutylester) on Bone Resorption in Vitro and in Vivo ....Pages 179-182
Lipid Peroxidation and Cyclooxygenase-2 Activity in Human Hepatocellular Carcinoma Cell Lines with and without Multiple Drug Resistance: Correlation with Cell Growth....Pages 183-186
Pulmonary Prostacyclin Synthase Overexpression Improves Survival Following Butylated Hydroxytoluene Exposure....Pages 187-190
Reactive Products of the Isoprostane Pathway: Isoketals and Cyclopentenone A 2 /J 2 -Isoprostanes....Pages 191-195
Increased Isoprostane 8-epi-PGF 2A in Statin-Induced Myopathy....Pages 197-199
Back Matter....Pages 201-205