Advances in Pharmacology and Chemotherapy Volume 19

Front Cover......Page 1
Advances in Pharmacology and Chemotherapy, Volume 19......Page 4
Copyright Page......Page 5
Contents......Page 6
Contributors to this Volumes......Page 10
II. Development of New Chloroethylnitrosoureas......Page 12
III. Chemistry......Page 16
IV. Reactive Intermediates......Page 20
V. Active Species......Page 24
VI. Mechanism of Cytotoxicity......Page 26
VII. Biodisposition......Page 31
VIII. Chemicobiological Interactions......Page 37
IX. Conclusion......Page 38
References......Page 39
I. Introduction......Page 46
II. Effects of Chemotherapeutic Agents on Mononuclear Phagocytes......Page 48
III. Effects of Chemotherapeutic Agents on Tumor-Associated Macrophages (TAM)......Page 67
IV. Antitumor Efficacy and Modulation of Mononuclear Phagocytes......Page 68
V. Concluding Remarks......Page 72
References......Page 73
I. Introduction......Page 78
II. Chemistry and Pharmacology......Page 80
III. Benzimidazole Carbamates in Veterinary Medicine......Page 93
IV. Benzimidazole Carbamates in Human Medicine......Page 120
V. Conclusion......Page 129
References......Page 130
I. Summary......Page 140
II. Introduction......Page 141
III. The Parasites......Page 142
IV. The Human Host......Page 147
V. The Drugs......Page 149
VI. Therapeutic Intervention......Page 158
References......Page 162
I. Introduction......Page 166
II. General Background......Page 167
III. Structure Activity/Toxicity Determinants......Page 174
 IV. Medicinal Chemistry of Electron-Affinic Radiosensitizers......Page 184
 V. Summary and Perspectus for the Future......Page 209
References......Page 211
 I. Introduction......Page 218
II. Antineoplastic Therapy......Page 220
III. Central Nervous System Toxicity......Page 226
IV. Endocrine Organ Toxicity......Page 240
V. Skeletal Growth......Page 247
VI. Psychosocial Development......Page 248
References......Page 250
I. Historical......Page 260
II. Chemistry and Structure–Activity Relationships......Page 261
III. Biological Characteristics......Page 271
IV. Radiosensitization......Page 279
V. Pharmacology......Page 280
VI. Toxicology......Page 281
VII. Clinical......Page 285
VIII. Interactions of ICRF Compounds with Other Agents......Page 289
References......Page 297
Note Added in Proof......Page 301
Index......Page 302