Advances in Molecular Biology and Targeted Treatment for AIDS

Front Matter....Pages i-ix
Mechanistic Analysis of HIV-1 Reverse Transcriptase....Pages 1-19
Analyses of HIV Integration Components....Pages 21-26
DNA Cleaving Activity of Purified Human Immunodeficiency Virus Integration Protein....Pages 27-33
A Thermodynamic Analysis of the Binding of Nucleic Acid to HIV-1 Reverse Transcriptase....Pages 35-50
Rous Sarcoma Virus Gag Gene Sequences Affect Viral RNA Splicing and Stability....Pages 51-54
Ribonuclease H and Primer tRNA Binding Activities of HIV Reverse Transcriptase as Therapeutic Targets....Pages 55-68
Human-Specific Factors are Required for Tat-Mediated Trans-Activation of the HIV-1 and HIV-2 LTRs....Pages 69-77
Role of the TAR Element in Regulating HIV Gene Expression....Pages 79-91
Regulation of HIV-1 Gene Expression by the Tat Protein and the TAR Region....Pages 93-105
HIV-1 Tat: A Transcriptional Activator that Recognizes a Structured RNA Target....Pages 107-121
HIV-1 Tat trans -activates in the Absence of its Target....Pages 123-131
 Trans -Activation Requires the Binding of the HIV-1 Tat Protein to Tar RNA....Pages 133-143
The HIV-1 Tat Transactivator Contains an Arginine-Glycine-Aspartyl (RGD) Cell Adhesion Site....Pages 145-150
Inhibition of HIV-1 Replication by Mutant Tat Peptides....Pages 151-172
RNA — Protein Interactions Required for Rev Mediated Regulation of HIV Gene Expression....Pages 173-181
A 5’ Splice Site is Essential for REV and REX Regulation of HIV Envelope Protein mRNA Expression....Pages 183-188
Molecular Functional Studies of HIV-1 REV and NEF Proteins....Pages 189-201
Structure and Function of HIV and SIV Nef Proteins....Pages 203-216
Functional Analysis of the HIV-1 Gene Products vif and vpu ....Pages 217-223
Envelope Pseudotypes of HIV and HTLV....Pages 225-233
CD4- Pseudomonas Exotoxin: A Strategy for AIDS Therapy Based on Selective Killing of HIV-Infected Cells....Pages 235-244
Binding of a Reduced-Peptide Inhibitor and a Statine-Containing Inhibitor to the Protease from the Human Immunodeficiency Virus....Pages 245-249
A T Cell Clone Which Reflects the Functional Defects Observed in the T Cells of AIDS Patients....Pages 251-255
Roles of Nucleocapsid Cysteine Arrays in Retroviral Assembly and Replication: Possible Mechanisms in RNA Encapsidation....Pages 257-272
Regulated Proteolytic Processing within Mature Retroviral Capsids....Pages 273-280
Red Blood Cells Exposing CD4, as Competitive Inhibitors of HIV-1 Infection....Pages 281-299
Gene Therapy for AIDS....Pages 301-308
Discovery of a Novel Potent Inhibitor of HIV Infection....Pages 309-313
Antiretroviral Activity of Carbocyclic Nucleosides and Potential Use of Inosinate Dehydrogenase Inhibitors....Pages 315-321
Lipophilic 6-Halo-2′,3′-Dideoxypurine Nucleosides: Potential Antiretroviral Agents Targeting HIV-Associated Neurologic Disorders....Pages 323-333
Antiviral Evaluation of HIV-1 Specific Ribozyme Expressed in CD4+ HeLa Cells....Pages 335-343
Resistance of Influenza a Viruses to Amantadine and Rimantadine....Pages 345-353
Back Matter....Pages 355-365