Advances in Drug Delivery Systems, 6. Proceedings of the Sixth International Symposium on Recent Advances in Drug Delivery Systems, Salt Lake City, UT, U.S.A., February 21–24, 1993

Content: 
Front Matter, Page iii
Copyright, Page iv
Preface, Pages v-vi, James M. Anderson, Sung Wan Kim, Jindrich Kopeˆek, Kristine Knutson
SYMPOSIUM SPONSORS, Page vii
SYMPOSIUM CONTRIBUTORS, Page vii
Biologically engineered microstructures: controlled release applications, Pages 3-13, Joel.M. Schnur, Ronald Price, Alan S. Rudolph
New approaches to targeting bioactive compounds, Pages 15-35, Alexander V. Kabanov, Valery Yu. Alakhov
Mucosal delivery of macromolecules, Pages 37-44, C.D. Ebert, S.J. Heiber, S.C. Dave, S.W. Kim, D. Mix
Targeted delivery of diagnostic agents by surface-modified liposomes, Pages 45-58, Vladimir P. Torchilin, Vladimir S. Trubetskoy, Alexander M. Milshteyn, John Canillo, Gerald L. Wolf, Mikhail I. Papisov, Alexei A. Bogdanov, Jagat Narula, Ban An Khaw, Vladimir G. Omelyanenko
Influencing factors on in vitro micelle stability of adriamycin-block copolymer conjugates, Pages 59-65, Masayuki Yokoyama, Glenn S. Kwon, Teruo Okano, Yasuhisa Sakurai, Mayumi Naito, Kazunori Kataoka
SK&F 110679: comparison of absorption following oral or respiratory administration, Pages 67-77, P.L. Smith, S.E. Yeulet, D.R. Citerone, F. Drake, M. Cook, D.A. Wall, J. Marcello
Bioavailability of pulmonary delivered peptides and proteins: α-interferon, calcitonins and parathyroid hormones, Pages 79-85, J.S. Patton, P. Trinchero, R.M. Platz
Vaginal and reproductive system treatments using a bioadhesive polymer, Pages 87-94, Joseph R. Robinson, William J. Bologna
Paracellular transport of a proteolytically labile pentapeptide across the colonic and other intestinal segments of the albino rabbit: implications for peptide drug design, Pages 97-109, Wan-Ching Yen, Vincent H.L. Lee
Control of the disposition profiles of proteins in the kidney via chemical modification, Pages 111-119, Yoshinobu Takakura, Kiyoshi Mihara, Mitsuru Hashida
Drug delivery using biodegradable microspheres, Pages 121-129, Hiroaki Okada, Masaki Yamamoto, Toshiro Heya, Yayoi Inoue, Shigeru Kamei, Yasuaki Ogawa, Hajime Toguchi
Biodegradable microspheres for the delivery of oral vaccines, Pages 131-141, J. Mestecky, Z. Moldoveanu, M. Novak, W.-Q. Huang, R.M. Gilley, J.K. Staas, D. Schafer, R.W. Compans
pH/Temperature-sensitive polymers for macromolecular drug loading and release, Pages 143-152, Yong-Hee Kim, You Han Bae, Sung Wan Kim
Antibodies as targeting moieties: affinity measurements, conjugation chemistry and applications in immunoliposomes, Pages 155-166, James N. Herron, Christine A. Gentry, Sean S. Davies, Ai-ping Wei, Jinn-nan Lin
Approaches to improved antibody- and peptide-mediated targeting for imaging and therapy of cancer, Pages 167-173, Alan R. Fritzberg, Paul L. Beaumier, Becky J. Bottino, John M. Reno
Bacterial cell killing by antibody targeted photolysis: enhanced effect by OH radical generation, Pages 175-186, Louis Strong, Xiao-Ming Lu, Ronald G. Tompkins, Martin L. Yarmush
Antibody-directed enzyme prodrug therapy (Adept), Pages 187-193, K.D. Bagshawe
Targeting the vasculature of solid tumors, Pages 195-202, F.J. Burrows, P.E. Thorpe
Synthesis of the conjugate of superoxide dismutase with the copolymer of divinyl ether and maleic anhydride retaining enzymatic activity, Pages 203-209, Takashi Hirano, Takeshi Todoroki, Shuji Kato, Harumi Yamamoto, Paolo Caliceti, Francesco Veronese, Hiroshi Maeda, Shinichi Ohashi
Bioadhesive N-(2-hydroxypropy1) methacrylamide copolymers for colon-specific drug delivery, Pages 211-222, P. Kopeˆková, R. Rathi, S. Takada, B. Říhová, M.M. Berenson, J. Kopeˆek
Lactose-carrying polystyrene as a drug carrier: investigation of body distributions to parenchymal liver cells using 125I-labelled lactose-carrying polystyrene, Pages 223-233, Mitsuaki Goto, Hirohumi Yura, Chia-Wun Chang, Akira Kobayashi, Tatsuki Shinoda, Atsushi Maeda, Seiki Kojima, Kazukiyo Kobayashi, Toshihiro Akaike
Induction of drug specific antibody and the controlled release of drug by 6-O-carboxymethyl-chitin, Pages 235-241, Seiichi Tokura, Yoshiaki Miura, Masayoshi Johmen, Norio Nishi, Shin-Ichiro Nishimura
Recent clinical studies on lipo-PGE1 and lipo-PGI2: PGE1 and PGI2 incorporated in lipid microspheres, for targeted delivery, Pages 243-249, Y. Mizushima, T. Toyota, K. Okita, E. Ohtomo
Encapsulated cells for sustained neurotransmitter delivery to the central nervous system, Pages 253-258, P.A. Tresco
Drug transport to the brain: in vitro versus in vivo approaches, Pages 259-263, A.G. de Boer, H.E. de Vries, E.C.M. de Lange, M. Danhof, J. Kuiper, D.D. Breimer
BUCCAL ADMINISTRATION OF ERYTHROCYTE-GHOSTS-INSULIN IN RATS, Pages 267-268, A. Al-Achi, R. Greenwood, B. Walker
In-Vivo Buccal Delivery of Calcitonin, Pages 269-271, S.J. Heiber, C.D. Ebert, S.C. Dave, K. Smith, S.W. Kim, D. Mix
INVESTIGATING THE BIOADHESIVE PROPERTIES OF POLYMER PATCHES FOR BUCCAL DRUG DELIVERY, Pages 272-273, J-H Guo
DIFFUSION RATES AND TRANSPORT PATHWAYS OF FITC-LABELLED MODEL COMPOUNDS THROUGH BUCCAL EPITHELIUM, Page 274, A.J. Hoogstraate, C. Cullander, S. Senel, J.C. Verhoef, H.E. Boddé, H.E. Junginger
ENHANCING EFFECTS OF VARIOUS STRUCTURES OF UNSATURATED FATTY ACIDS ON THE PERCUTANEOUS PERMEATION OF INDOMETHACIN, Pages 275-276, K. Morimoto, H. Tojima, M. Kakemi, M. Suzuki
SELECTIVE EXTRACTION OF STRATUM CORNEUM COMPONENTS TO PROBE MECHANISMS OF ENHANCED PERCUTANEOUS ABSORPTION, Pages 277-278, R. Oakeson, C.Y. Goates, K. Knutson
STUDY ON TRANSDERMAL SODIUM NITROPRUSSIDE DELIVERY SYSTEM, Pages 279-281, B.Q. Ji, C.M. Jiang, T.H. Gu, Z.Y. Zhang
WATER SOLUBLE PILOCARPINE PRODRUGS WITH SUSTAINED INTRAOCULAR ACTIVITY IN NORMOTENSIVE RABBITS AND IN GLAUCOMATOUS BEAGLES, Pages 282-283, P. Druzgala, N. Bodor
TRANSPORT OF SMALL PEPTIDES ACROSS RAT ALVEOLAR EPITHELIAL CELL MONOLAYERS, Pages 284-285, K. Morimoto, H. Yamahara, K.J. Kim, E.D. Crandall, V.H.L. Lee
RECEPTOR–MEDIATED ABSORPTION OF DEXTRAN AND SYNTHETIC GLUCOSE–CONTAINING POLYMER FROM THE INTESTINAL TRACT, Pages 286-287, Y. Koyama, T. Miyagawa, H. Suzuki, A. Kawaide, K. Kataoka
EFFECT OF POLYCARBOPHIL ON THE PARACELLULAR PERMEABILITY OF A HYDROPHILIC MODEL COMPOUND AFTER APPLICATION ON A CACO-2 CELL LINE, Page 288, H.L. Lueβen, A.B.J. Noach, A.G. de Boer, J.C. Verhoef, H.E. Junginger
USE OF A LIPID CARRIER TO DELIVER CALCITONIN VIA THE SMALL INTESTINE, Pages 289-290, R.R.C. New, P. Guard, P. Hotten, D. Stevens, R. Harris, T. Shepherd, M.J. Flynn
INTRAVENOUS CARRIERS FOR DRUG DELIVERY TO LYMPH NODES, Pages 293-294, M.I. Papisov, R. Weissleder, B. Schaffer, A.A. Bogdanov Jr., T.J. Brady
TARGETED CONJUGATE BETWEEN ANTIMYOSIN AND RADIOLABELED CHELATING POLYMER: INFLUENCE OF SINGLE SITE FAB-POLYMER BOND ON THE CONJUGATE PERFORMANCE, Pages 295-296, V.S. Trubetskoy, V.P. Torchilin, J. Narula, B.A. Khaw
STEREOCOPOLYMERS FOR PARENTERAL SUSTAINED-RELEASE OF PEPTIDES: RELEASE OF GRF29NH2 FROM A PLA/GA MATRIX, Pages 297-298, B. Mariette, M. Vert, J. Coudane
THE EFFECT OF CHARGE ON THE BIODISTRIBUTION OF SYNTHETIC BRANCHED POLYPEPTIDES IN TUMOUR BEARING MICE, Pages 301-302, F. Hudecz, Y. Kojima, Y Miyamoto, J. Kajtár, H. Maeda
COMPARATIVE IN VIVO AND IN VITRO DISTRIBUTION OF DAUNOXOME AND DAUNORUBICIN IN P1798 LYMPHOSARCOMA CELLS, Pages 303-304, J. Adler-Moore, G. Fujii, E.A. Forssen, M.J.A. Lee, A. Bailey, D.M. Coulter, T. Bunch
BIOPHARMACEUTICS AND PHARMACOKINETICS OF [D-ALA2, D-LEU5]ENKEPHALIN AFTER VARIOUS ROUTES OF ADMINISTRATION, Page 305, H.J. Lee, G.L. Amidon, L.Y. Yek
Greatly enhanced oral bioavailability of propranolol using the HALOTM liver-bypass drug delivery system, Pages 306-309, S.G. Barnwell, L. Gauci, R.J. Harris, D. Attwood, G. Littlewood, P. Guard, M.E. Pickup, P. Barrington
NOVEL, LONG-ACTING AND SELECTIVE PHYSOSTIGMINE ANALOGUES AS POTENTIAL THERAPEUTICS FOR ALZHEIMER'S DISEASE, Page 313, Nigel H. Greig, Arnold Brossi, Timothy T. Soncrant, Harold W. Holloway, Xue Feng Pei, Stanley I. Rapoport, Donald K. Ingram
LECITHINIZED SUPEROXIDE DISMUTASE -AN EFFECTIVE DRUG DELIVERY SYSTEM-, Pages 314-315, R. IGARASHI, J. HOSHINO, M. TAKENAGA, S. KAWAI, Y. MORIZAWA, A. YASUDA, Y. MIZUSHIMA
TWO DERIVATIVES OF POLY(ACRYLIC ACID) ARE ABLE TWO INHIBIT TRYPSIN ACTIVITY, Page 316, H.L. Lueβen, J.C. Verhoef, C.-M. Lehr, A.G. de Boer, H.E. Junginger
CONTROLLED RELEASE OF INSULIN FROM BORONIC ACID GEL UNDER PHYSIOLOGICAL CONDITIONS, Pages 317-318, D. Shiino, K. Kataoka, Y. Koyama, M. Yokoyama, T. Okano, Y. Sakurai
NOVEL THERMO-RESPONSIVE AMPHIPHILIC POLY N-ISOPROPYLACRYL-AMIDE-CO-SODIUM ACRYLATE-CO-N-N-ALKYLACRYLAMIDE NETWORKS, Pages 319-320, D.W. Grainger, H. Yu
DELIVERY OF CYTOTOXIC DRUGS TO CANCER PATIENTS USING LOW DENSITY LIPOPROTEIN, Pages 321-322, A.S. Breeze, L. Gauci, D. Filipowska, T. Laudanski
DEVELOPMENT AND CLINICAL EVALUATION OF DOUBLE-PHASED SUPPOSITORIES OF PROGESTERONE WITH SUSTAINED RELEASE PROPERTY, Pages 323-324, M. Iwata, S. Shirotake, F. Hirahara, H. Minaguchi, Y. Machida, T. Nagai
MACROMOLECULAR COMPLEXONE FOR DETECTION OF MICROVASCULATURE BY MAGNETIC RESONANCE ANGIOGRAPHY, Pages 325-326, A. Bogdanov Jr., R. Weissleder, E. Tsai, B. Schaffer, A. Bogdanova, N. Nossiff, M. Papisov, T. Brady
CRIPDOM CONTROLLED DELIVERY SYSTEM FOR ASPIRIN, Pages 327-328, V. Azuree, J P Selles
EFFECT OF LIPID BILAYER PHASE STRUCTURE ON SOLUTE PARTITIONING, Pages 331-333, M. Marra-Feil, K. Knutson
ENHANCED TUMOR ACCUMULATION AND PROLONGED CIRCULATION TIMES OF MICELLE-FORMING POLY(ETHYLENE OXIDE-ASPARTATE) BLOCK COPOLYMER-ADRIAMYCIN CONJUGATES, Pages 334-335, G.S. Kwon, M. Yokoyama, T. Okano, Y. Sakurai, K. Kataoka
IN VIVO ANTITUMOR ACTIVITY OF POLYMERIC MICELLE ANTICANCER DRUG AGAINST MURINE C 26 TUMOR, Pages 336-337, M. Yokoyama, G.S. Kwon, T. Okano, Y. Sakurai, H. Ekimoto, K. Kataoka
METHOD FOR ASSESSING THE STABILITY OF PROTEINOID MICROSPHERES, Pages 338-339, R.A. Baughman, S. Haas, S. Milstein, N. Santiago
SCREENING CANDIDATE MICROSPHERE FORMULATIONS BY INCUBATING IN SIMULATED DIGESTIVE FLUIDS, Pages 340-341, R.A. Baughman, S. Haas, S. Milstein, N. Santiago
STABILITY AND MODE OF ACTION OF AMBISOME® (LIPOSOMAL AMPHOTERICIN B), Pages 342-343, R.T. Proffitt, J. Adler-Moore, G. Fujii, A. Satorius, M.J.A. Lee, A. Bailey
APPLICATION OF LIPID MICROSPHERES TO PREPARE A THROMBOXANE A2 RECEPTOR ANTAGONIST INHALER, Pages 344-345, M. Takenaga, T. Nakagawa, R. Igarashi, Y. Mizushima
AEROSOLIZATION OF LIPOSOMAL (AMBISOME®) AND NON-LIPOSOMAL (FUNGIZONE®) AMPHOTERICIN B AS A TREATMENT FOR PULMONARY FUNGAL INFECTIONS, Pages 346-347, K.N. Sorensen, S.D. Alleni, M.J. Nejdl, R.T. Proffitt
EFFICACY OF AEROSOLIZED LIPOSOMAL AMPHOTERICIN B (AMBISOME®) AS A PROPHOLACTIC TREATMENT IN AN IMMUNE COMPROMISED MURINE MODEL OF PULMONARY ASPERGILLOSIS, Pages 348-349, S.D. Allen, K.N. Sorensen, M.J. Nejdl, R.T. Proffitt
EFFICACY OF ALBENDAZOLE ADMINISTERED ORALLY IS IMPROVED BY ENCAPSULATION IN LIPOSOMES, Pages 350-351, R.R.C. New, H. Wen, P.S. Craig, P.F. Zou, A. Merdan, J.H. Wang, Y.H. Wang, P. Wang, J.H. Zhang
LIPID NANO-SPHERE(LNS), A PROTEIN-FREE ANALOGUE OF LIPOPROTEINS, AS A NOVEL DRUG CARRIER FOR PARENTERAL ADMINISTRATION. IV, Pages 352-353, J. Seki, H. Sasaki, M. Doi, H. Yoshikawa, Y. Takahashi, S. Yamane, H. Fukui, S. Sonoke, H. Yamamoto, M. Hirose, Y. Ezure, T. Ando, K. Ushimaru, M. Sugiyama
MICROENCAPSULATION OF MITOMYCIN C FOR CONTROLLED DELIVERY AND TARGETING, Pages 354-355, T L Whateley, J G Eley, I Crossan, P B Deasy
Author Index Volume 28, Pages 357-358
Subject Index Volume 28, Pages 359-360