Advances in Alzheimer’s and Parkinson’s Disease: Insights, Progress, and Perspectives

Front Matter....Pages I-XXX
Clinical Features and Treatment of Dementia Associated With Parkinson’s Disease....Pages 1-7
Neurogenetics in Parkinson\'s Disease....Pages 9-16
Impaired DNA Repair Systems: Generation of Mitochondrial Dysfunction and Increased Sensitivity to Excitotoxicity....Pages 17-21
Current Problems and Strategies in Motor Rehabilitation for Parkinson’s Disease....Pages 23-30
Critical Acute Akinesia in Parkinson’s Disease Patients Concomitant with Additional Precipitating Factors Other Than Treatment Withdrawal: A Possible Lethal Complication....Pages 31-34
Biomarkers for Early Detection of Parkinson’s Disease: An Essential Challenge....Pages 35-49
Neurotransmitter and Neurotrophic Factor-Secreting Cell Line Grafting for the Treatment of Parkinson’s Disease....Pages 51-56
Novel Therapeutic Target in PD: Experimental Models....Pages 57-73
LRRK2 (Leucine-Rich Repeat Kinase 2) Gene on PARK8 Locus in Families with Parkinsonism....Pages 75-89
Microglia Activation and Gene Expression of Cytokines in Parkinson’s Disease....Pages 91-95
Dissecting the Biochemical Pathways Mediated by Genes Implicated in Parkinson’s Disease: Induction of DJ-1 Expression in A30P α-Synuclein Mice....Pages 97-112
Neuroinflammation in Early Stages of Alzheimer’s Disease and Parkinson’s Disease....Pages 113-121
Alzheimer’s Disease, Parkinson’s Disease, and Frontotemporal Dementias: Different Manifestations of Protein Misfolding....Pages 123-131
Role of Oxidative Insult and Neuronal Survival in Alzheimer’s and Parkinson’s Diseases....Pages 133-148
Redox Proteomics Identification of Oxidatively Modified Proteins in Alzheimer’s Disease Brain and in Brain from a Rodent Model of Familial Parkinson’s Disease: Insights into Potential Mechanisms of Neurodegeneration....Pages 149-167
Biomarkers for Alzheimer’s Disease and Parkinson’s Disease....Pages 169-174
Bioluminescent Imaging of Excitotoxic and Endotoxic Brain Injury in Living Mice....Pages 175-182
Alzheimer’s Disease Neuroimaging Initiative....Pages 183-189
Two Hits and You’re Out? A Novel Mechanistic Hypothesis of Alzheimer Disease....Pages 191-204
Vascular Risk Factors and Risk for Alzheimer’s Disease and Mild Cognitive Impairment: Population-Based Studies....Pages 205-209
Cholesterol Transport and Production in Alzheimer’s Disease....Pages 211-219
Cholesterol and Aβ Production: Methods for Analysis of Altered Cholesterol De Novo Synthesis....Pages 221-230
Glycosaminoglycans and Analogs in Neurodegenerative Disorders....Pages 231-245
Prospective Role of Glycosaminoglycans in Apoptosis Associated with Neurodegenerative Disorders....Pages 247-254
Stem Cell Therapy in Alzheimer’s Disease....Pages 255-264
Oral Aβ Vaccine Using a Recombinant Adeno-Associated Virus Vector in an Alzheimer’s Disease Mouse Model....Pages 265-272
In Vivo Targeting of Amyloid Plaques Via Intranasal Administration of Phage Anti-β-Amyloid Antibodies....Pages 273-278
Decreased ProBDNF: The Cause of Alzheimer’s-Associated Neurodegeneration and Cognitive Decline?....Pages 279-283
Shift in the Balance of TRKA and ProNGF in Prodromal Alzheimer ’s Disease....Pages 285-290
Neuroprotective Effects of Trophic Factors and Natural Products: Involvement of Multiple Intracellular Kinases....Pages 291-296
Intraneuronal Aβ and Alzheimer’s Disease....Pages 297-304
Physiological Processing of the Cellular Prion Protein and βAPP: Enzymes and Regulation....Pages 305-316
Expression of Wnt Receptors, Frizzled, in Rat Neuronal Cells....Pages 317-324
Cell Models of Tauopathy....Pages 325-336
Co-expression of FTDP-17 Human Tau and GSK-3ß (or APP SW ) in Transgenic Mice: Induction of Tau Polymerization and Neurodegeneration....Pages 337-342
Enhanced Activation of NF-κB Signaling by Apolipoprotein E4....Pages 343-353
Pleiotropic Effects of Apolipoprotein E in Dementia: Influence on Functional Genomics and Pharmacogenetics....Pages 355-367
Up-regulation of the α-Secretase Pathway....Pages 369-374
Frequency and Relation of Argyrophilic Grain Disease and Thorn-Shaped Astrocytes in Alzheimer’s Disease....Pages 375-379
Cellular Membranes as Targets in Amyloid Oligomer Disease Pathogenesis....Pages 381-386
Ganglioside-Dependent Generation of a Seed for Alzheimer’s Disease Amyloid....Pages 387-392
Evidence That Amyloid Pathology Progresses in a Neurotransmitter-Specific Manner....Pages 393-401
Rationale for Glutamatergic and Cholinergic Approaches for the Treatment of Alzheimer’s Disease....Pages 403-409
Cortical Cholinergic Lesion Causes Aβ Deposition: Cholinergic-Amyloid Fusion Hypothesis....Pages 411-427
Expression of Acetylcholinesterase in Alzheimer’s Disease Brain: Role in Neuritic Dystrophy and Synaptic Scaling....Pages 429-437
Role of b-Amyloid in the Pathophysiology of Alzheimer’s Disease and Cholinesterase Inhibition: Facing the Biological Complexity to Treat the Disease....Pages 439-444
Dissociation Between the Potent β-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine....Pages 445-462
Allosteric Potentiators of Neuronal Nicotinic Cholinergic Receptors: Potential Treatments for Neurodegenerative Disorders....Pages 463-472
Back Matter....Pages 473-489