Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

Front Matter....Pages II-XXIV
Front Matter....Pages 1-1
Controlled Release Systems Using Swellable Random and Block Copolymers and Terpolymers....Pages 3-7
Polymer Gel-A New Type of Soft Energy Transducer....Pages 8-12
Communicating with the Building Blocks of Life Using Advanced Macromolecular Transducers....Pages 13-17
Water-Soluble Nucleic Acid Analogs — Preparation and Properties....Pages 18-22
Intelligent Materials....Pages 23-27
Functional Synthetic and Semisynthetic Polymers in Biomedical Applications....Pages 28-31
Bioconjugates from Synthetic Polymers -How they can be married?-....Pages 32-37
Plasma Modification of Polymeric Surfaces for Biomedical Applications....Pages 38-42
New Polymeric Materials Design for Biomedical Applications....Pages 43-47
Front Matter....Pages 49-49
New Oral Drug Delivery System....Pages 51-56
Penetration of Polymeric Drug Carriers into K562 Cells....Pages 57-61
Novel Bioadhesive, pH- and Temperature-Sensitive Graft Copolymers for Prolonged Mucosal Drug Delivery....Pages 62-66
Enhanced Intestinal Absorption of Peptides by Complexation of the Partially Denatured Peptide....Pages 67-70
Controlled Drug Delivery Formulation with Safe Polymers....Pages 71-75
Supramolecular Assemblies for Improved Drug Delivery System....Pages 76-80
Biodegradable Polyphosphazenes for Biomedical Applications....Pages 81-85
Receptor-Mediated Cell Specific Delivery of Drugs to the Liver and Kidney....Pages 86-90
Biorecognizable Biomedical Polymers....Pages 91-95
Nanoscopic Vehicles with Core-Shell Structure for Drug Targeting....Pages 96-100
Third Phase in Polymer Drug Development: — Smancs as a Prototype Model Drug for Cancer Treatment —....Pages 101-105
Front Matter....Pages 49-49
Development of a Tetracycline Delivery System for the Treatment of Periodontal Disease Using a Semisolid Poly(Ortho Ester)....Pages 106-110
Mechanistic Aspects of Transdermal Drug Transport....Pages 111-115
Transbuccal Delivery of Polar Compounds....Pages 116-120
Receptor-Mediated Targeting of Peptides and Proteins....Pages 121-125
Temperature Sensitive Polymers for Delivery of Macromolecular Drugs....Pages 126-133
Front Matter....Pages 135-135
Novel Biomaterials as Artificial Cornea via Plasma Induced Grafted Polymerization....Pages 137-141
Ultrathin Polymeric Films as Biomedical Interfaces of Controlled Chemical Architecture....Pages 142-146
Randomness and Biospecificity : Random Copolymers are Endowed with Biospecific Properties....Pages 147-152
Strategy and Bionic Design of Vital Functioning Vascular Wall Reconstruction....Pages 153-157
Surface Modification of Biomaterials by Topographic and Chemical Patterning....Pages 158-162
Interleukin-4 Mediated Foreign Body Giant Cell Formation and Cytoskeletal Rearrangement on Poly(etherurethane Urea) In Vivo and In Vitro ....Pages 163-167
Polymer-Supported Tissue Engineering....Pages 168-172
New Frontier of Biomimetic Glycotechnology for Cellular and Tissue Engineering....Pages 173-178
Control of Healing with Photopolymerizable Biodegradable Hydrogels....Pages 179-182
A Novel Biomateral: Aramid-Silicone Resin....Pages 183-187
Gradient Surfaces as Tools to Study Biocompatibility....Pages 188-192
Preparation of Self-Assembled Biomimetic Membranes and Their Functions....Pages 193-197
Synthesis and Cell-Adhesion Properties of Polyurethanes Containing Covalently Grafted RGD-Peptides....Pages 198-202
Front Matter....Pages 203-203
One Pot Synthesis of Poly(Ethylene Oxide) with a Cyano Group at one End and a Hydroxyl Group at the Other End....Pages 205-206
Creation of New Si-containing Block Copolymer Membrane with Both High Gas Permeability and Blood compatibility....Pages 207-208
Front Matter....Pages 203-203
Surface Modification of Poly(Lactic Acid) with Bioactive Peptides....Pages 209-210
Adsorption of Biomolecules onto Multiblock Copolymer Consisting of Aromatic Polyamide and Poly(Dimethylsiloxane)....Pages 211-212
Hemocompatible Cellulose Dialysis Membrane Modified with Phospholipid Polymer....Pages 213-214
Artificial Glycoconjugate Polymers: Cell-Specific Biomedical Materials Using Carbohydrates as Recognition Signals....Pages 215-216
Preparation of Acrylamide Coated PVC Tube by APG Treatment and Its Characterization....Pages 217-218
Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer....Pages 219-220
Histological and Morphological Comparison of Explanted Small Diameter PU and ePTFE Vascular Prostheses: A Preliminary Study....Pages 221-222
Poly (Acrylamides) Containing Sugar Residues :Synthesis, Characterization and Cell Compatibility Studies....Pages 223-224
Molecular Design of Artificial Lectin; Recognition and Killer Cell Induction of Lymphocytes by a Novel Water Soluble Polymer Having Phenylboronic Acid Moiety....Pages 225-226
Selective Adhesion and Spontaneous Fusion of Platelets on Polyion Complex Composed of Phospholipid Polymers....Pages 227-228
Thermo-Responsive Polymer Surfaces for Cell Culture: Analysis of the Surfaces and Control of the Cell Attachment / Detachment....Pages 229-230
Rgds-Carrying Latex Particles for Cell Activation and Integrin Separation....Pages 231-232
Estimation of the Secondary Structure of Fibronectin Adsorbed to Polystyrene and Deprotected Poly(ε- N -Benzyloxycarbonyl-L-Lysine) by FTIR ATR Spectroscopy....Pages 233-234
Hybrid Biomaterials Comprising Double-Helical DNA. Covalent Coupling Between λ Phage DNA and Poly(N-Isopropylacrylamide)....Pages 235-236
Preparation of Glucose-Sensitive Hydrogels by Entrapment or Copolymerization of Concanavalin a in a Glucosyloxyethyl Methacrylate Hydrogel....Pages 237-238
Complexation of Neocarzinostatin Chromophore with a Hydrophobized Polysaccharide as an Apoprotein Model....Pages 239-240
Hydrolytic Degradation of Poly(L-Lactide-co-ε-Caprolactone)S....Pages 241-242
Selective Adsorption of Plasma Protein Onto Phase-Separated Domain of Immobilized Organosilane Monolayer Surfaces....Pages 243-244
The Possibility of the Constitution of an Artificial Thymus by Utilizing Keratinocytes....Pages 245-246
Improved Nonthrombogenicity of Heparin Immobilized and Sulfonated Polyurethane: In Vitro Evaluation Using Epifluorescent Video Microscopy....Pages 247-248
Front Matter....Pages 203-203
Evaluation of a Newly Developed Biological Patch....Pages 249-250
Application of Hema-St Block Copolymer Coated Small Caliber Vascular Graft for Veins....Pages 251-252
Transfer and Surface Fixation of Gels by an Excimer Laser Ablation....Pages 253-254
PVA Hydrogel as an Artificial Vitreous Body....Pages 255-256
Analysis of Plasma Membrane Glycocalyx and/or of Quantitative Computerized Cytological Image of Platelets Adhered to Hema-St ABA Type Block Copolymer Surfaces with Good Antithrombogenicity....Pages 257-258
Immobilization of Human Thrombomodulin Onto Biomaterials: Evaluation of Antithrombogenicity Using Small Dialyzer....Pages 259-260
Surface Characterization of Hema-Styrene Block Copolymer Using Transmission Electron Microscopy....Pages 261-262
Induction of Endothelial Cell Differentiation on Copolymer Surfaces Having Phenylboronic Acid Groups....Pages 263-264
Immobilization of Biosignal Proteins to Control Cellular Functions....Pages 265-266
Temperature-Modulated Surface Hydrophilic/Hydrophobic Alterations for Novel Recovery of Cultured Cells....Pages 267-268
Cell Cultures on Plasma-Modified Nylon Meshes and Collagen/Nylon Composite Biomatrix....Pages 269-270
Direct Extraction of Taste Receptor Proteins by Liposome from Intact Epithelium of Bullfrog Tongue....Pages 271-272
The Influence of Serum on The Spreading of Tumor Cells on Synthetic Glycolipid Films....Pages 273-274
Transfer of Membrane Proteins from Human Erythrocytes to Liposomes....Pages 275-276
Reconstitution of Bovine Placental Insulin Receptor on Artificial Vesicles by Using Direct Protein Transfer Techniques....Pages 277-278
Protein Reconstitution from Cell Membrane to Monolayer Using Direct Transfer Technique....Pages 279-280
Glucose Responsive Inter-Polymer Complex Gel Based on the Complexation Between Boronic Acid and Polyols —Mechanism of Gelation and Glucose Exchange—....Pages 281-282
Synthesis of Ionic Polyurethane Elastomers as Chemomechanical Materials....Pages 283-284
A Synthetic Polyanion Polymer as a Growth Promoter for L929 Mouse Fibroblast....Pages 285-286
Adhesion of Fibroblast onto Poly(γ-Benzyl L-Glutamate)/Poly(Ethylene Oxide) Diblock Copolymer Langmuir-Blodgett Films....Pages 287-288
Front Matter....Pages 203-203
New Bioactive Macromolecular Glycolipids from Bacterial Cell Surface....Pages 289-290
 13 C-Labeling in Methionine Methyl Groups of Glycophorin A M and Its Effect on the Secondary Structure....Pages 291-292
Stabilization of Enzyme by Polymer with Pendant Monosaccharide....Pages 293-294
Molecular Architecture of Temperature-Responsive Bioconjugates....Pages 295-296
Stabilization of L-Asparaginase by Chemical Modification with Poly(Ethylene Glycol) Derivatives....Pages 297-298
New Polymeric Hydrogels for the Removal of Uraemic Toxins....Pages 299-300
Estimation of Biocompatibility of Polymeric Materials Using RT-PCR Method....Pages 301-302
Temperature Responsive Swelling-Deswelling Kinetics of Poly( N -Isopropylacrylamide) Grafted Hydrogels....Pages 303-304
Temperature-Sensitive Changes in Surface Properties of a Poly(N-Isopropylacrylamide) Hydrogel Layer....Pages 305-306
Efect of Anion-Exchange Capacity and Porosity of Polyethyleneimine-Immobilized Cellulose Fibers on Selective Removal of Endotoxin....Pages 307-308
Cellular communication with conducting electroactive polymers....Pages 309-310
Front Matter....Pages 311-311
Stimuli-Sensitive Release of Lysozyme from Hydrogel Containing Phosphate Groups....Pages 313-314
Slow Release of Heparin from a Hydrogel Made from Polyamine Chains Grafted to a Temperature-Sensitive Polymer Backbone....Pages 315-316
Formation of core-shell type nano-associates through electrostatic interaction between peptide and block copolymer with poly(ethylene glycol) segment....Pages 317-318
PEG-Poly(lysine) block copolymer as a novel type of synthetic gene vector with supramolecular structure....Pages 319-320
Development of Polymeric Micelles for Drug Delivery of Indomethacin....Pages 321-322
Synthesis of heterobifunctional poly(ethylene glycol) with a reducing monosaccharide residue at one end for drug delivery....Pages 323-324
Functional Polymeric Micelles: Synthesis and Characterization....Pages 325-326
Micelle Forming Polymeric Anticancer Drug Containing Chemically Bound and Physically Incorporated Adriamycin....Pages 327-328
Pharmaceutical Aspects of Block Copolymer Micelles....Pages 329-330
Front Matter....Pages 311-311
Nanosize Hydrogel Formed by Self-Assembly of Hydrophobized Polysaccharides....Pages 331-332
Novel Design of Supramolecular-Structured Biodegradable Polymer for Drug Delivery....Pages 333-334
Interaction of Poly(ethylene Oxide)-Bearing Lipid Reconstituted Liposomes With Murine B16 Melanoma Cells....Pages 335-336
Physical Stabilization of Insulin through Chemical Modification: Site-Specific Glycosylation or Pegylation....Pages 337-338
Therapeutic Effects of the Soybean Trypsin Inhibitor and Its Gelatin Conjugate on the Pseudomonal Elastase Induced Shock in Guinea Pig....Pages 339-340
The Pulsatile Release System of Macromolecular Drugs from Alginate Gel Beads....Pages 341-342
Albumin Release from Bioerodible Hydrogels Based on Semi-Interpenetrating Polymer Networks Composed of Poly(ε-Caprolactone) and Poly (Ethylene Glycol) Macromer....Pages 343-344
A Novel Drug Delivery System of Hepatocyte Growth Factor (HGF): Utilization of Heparin-HGF Complex....Pages 345-346
New Polymeric Hydrogel Formulations for the Controlled Release of Proteic Drugs. DSC Investigation of Water Structure....Pages 347-348
Degradation Mechanism of AZO-Containing Polyurethanes by the Action of Intestinal Flora....Pages 349-350
Novel Immunoliposomes Modified with Amphipathic Polyethyleneglycols Conjugated at their Distal Terminals to Monoclonal Antibodies....Pages 351-352
Photo-Induced Drug Release from Liposome Using Photochromic Lipid Having Spiropyran Group....Pages 353-354
New Structurally Modified Cyclodextrins for Controlled Release of Antihypertensive Drugs....Pages 355-356
Development of Delivery Systems for Antisense Oligonucleotides....Pages 357-358
Transfection to Smooth Muscle Cells Using Terplex of LDL, DNA, and Hydrophobized Cationic Polymers....Pages 359-360
Preparation of Ammonio-Terminated Polyoxyethylene/Polydimethylsiloxane Block Copolymer and Application to Transdermal Penetration Enhancer....Pages 361-362
Theoretical Design of Skin Penetration Enhancement Via Prodrug-Enhancer Combination Based on a Diffusion Model....Pages 363-364
Preparation of Biodegradable Microspheres Containing Water-Soluble Drug, β-Lactam Antibiotic....Pages 365-366
Effect of Micropore Structure on Drug Release Form Self-Setting Calcium Phosphate Cement Containing Anti-Cancer Agent....Pages 367-368
Amine Effect on Controlled Release of Insulin from Phenylboronic Acid Gel in Physiological pH....Pages 369-370
Front Matter....Pages 311-311
Drug Releasing Mechanism from Redox Active Micelles....Pages 371-372
Back Matter....Pages 373-381