Acute Respiratory Distress Syndrome: Cellular and Molecular Mechanisms and Clinical Management

Front Matter....Pages i-xv
Regulation of the Sodium Pump in Hyperoxic Lung Injury....Pages 1-12
Lung Edema Clearance During Hyperoxic Lung Injury....Pages 13-18
The Role of Lung Lymphatics in Pulmonary Edema Clearance....Pages 19-24
Molecular biology of lung Na + absorption....Pages 25-34
Regulation of Alveolar Sodium Transport by Hypoxia....Pages 35-44
Vectorial Movement of Sodium in Lung Alveolar Epithelium: Role and Regulation of Na + ,K + -ATPase....Pages 45-52
The Premature Infant’s Inability to Clear Fetal Lung Liquid Results in Respiratory Distress Syndrome (RDS)....Pages 53-63
Role of Matrix Macromolecules in Controlling Lung Fluid Balance: Transition From a Dry Tissue to Edema....Pages 65-68
Role of the Na,K-ATPase α 2 subunit in lung liquid clearance....Pages 69-70
Alveolar Epithelial Fluid Transport Under Normal and Pathological Conditions....Pages 71-85
Host Defense Capacities of Pulmonary Surfactant....Pages 87-96
Alteration of Pulmonary Surfactant in Ards - Pathogenetic Role and Therapeutic Perspectives....Pages 97-105
Surfactant Replacement in Patients with Ards: Results of Clinical Trials....Pages 107-116
Potential Role for Pulmonary Surfactant in Lung Transplantation....Pages 117-124
Preparation of Surfactant and Lipid Vectors for Delivery of Proteins and Genes to Tissue....Pages 125-131
Recombinant SP-C Based Surfactant Can Improve Lung Function in Saline Lavaged Sheep.....Pages 133-134
Gene Therapy for the Acute Respiratory Distress Syndrome....Pages 135-141
The Use of Recombinant Antioxidants in Neonatal....Pages 143-151
The Early Inflammatory Response in Acute Respiratory Distress Syndrome (ARDS)....Pages 153-158
The N -Nitroso- N -Methylurethane Induced Acute Lung Injury Animal Model for Ards: Minireview....Pages 159-164
Hyperoxia Induced Fibrosis in ARDS and BPd: Current Pathology and Cytokine Profiles....Pages 165-175
Map Kinases in Airway Disease: Standing at the Confluence of Basic and Clinical Science....Pages 177-186
Oxidant-Regulated Gene Expression in Inflammatory Lung Disease....Pages 187-195
Pulmonary Edema of Mixed or Incompletely Understood Pathogenesis....Pages 197-206
Biologic Markers of Acute Lung Injury....Pages 207-214
Pathways to Oxidative Cell Death....Pages 215-224
Divergent Effects of Hypoxia and Oxidants on Mitochondrial Superoxide Dismutase (MnSOD) Gene Expression....Pages 225-233
Cellular Sources Of Cytokines in Pulmonary Fibrosis....Pages 235-243
Strategies to Speed Lung Healing in ARDS....Pages 245-253
Pulmonary Microvascular Occlusion in Aggregate Anaphylaxis....Pages 255-258
The Expression of ICAM-1 and P-Selectin Are Increased Following Hemorrhage and Resuscitation in Mice....Pages 259-261
Increased Levels of Markers of Protein Oxidation in Bronchoalveolar Lavage Fluid from Patients With ARDS....Pages 263-264
The Use of P.E.E.P. in the Treatment of A.R.D.S.....Pages 265-274
Tracheal Gas Insufflation....Pages 275-283
Mechanical Ventilation in Ards: Good or Bad News?....Pages 285-292
Ventilator-Induced Lung Injury in Patients with Ards....Pages 293-302
Mechanical Ventilation for Ards: Should we Reduce Tidal Volume?....Pages 303-309
Endotracheal Tubes Resistance and Passive Expiratory Time During Mechanical Ventilation in Ards....Pages 311-318
Use of Liquid Ventilation in Animal Models of Ards....Pages 319-327
Inhaled Prostacyclin For The Treatment Of ARDS....Pages 329-332
Has Prognosis of ARDS Improved?....Pages 333-339
Effect of Ventilation Strategy on Cytokine Expression in an Ex Vivo Lung Model....Pages 341-342
Abnormal Tissue Oxygenation and Cardiovascular Changes in Endotoxaemia: Beneficial Effects of Volume Resuscitation.....Pages 343-344
Mechanisms of Nitric Oxide Induced Injury to the Alveolar Epithelium....Pages 345-354
Macrophage Killing of Mycoplasmas: Involvement of Surfactant Protein a and Nitric Oxide....Pages 355-364
Exhaled Nitric Oxide in Patients Undergoing C Ardiothoracic Surgery: a New Diagnostic Tool?....Pages 365-374
ARDS: Nitric Oxide as Cause and Therapy in Multiple Organ Failure (MOF)....Pages 375-383
Role of Reactive Nitrogen Species in Asbestos-Induced Pleuro-Pulmonary Injury....Pages 385-393
Biomarkers of Oxidative Stress in Adult Respiratory Distress Syndrome....Pages 395-400
Reactive Oxygen and Nitrogen Species and Adult Respiratory Distress Syndrome (ARDS): New Mechanisms to be Considered....Pages 401-414
Health and Science Legislation in the United States....Pages 415-420
Back Matter....Pages 421-432