Acute and Chronic Cough (Lung Biology in Health and Disease, Volume 205)

Introduction......Page 14
Preface......Page 16
Contributors......Page 20
Contents......Page 24
Introduction......Page 32
The TRP Channel Superfamily......Page 33
Molecular Characterization of TRPV1......Page 37
Studies in TRPV1-Deficient Mice......Page 42
Expression of TRPV1......Page 43
Functions of TRPV1 in the Airway......Page 44
TRPs in Nonneuronal Cells of the Airway......Page 45
References......Page 46
Introduction......Page 56
Classification of Airway Afferent Nerve Subtypes......Page 57
Properties of Airway Afferent Nerve Subtypes and Their Potential Role in Regulating Cough......Page 58
Other Airway Afferent Nerve Subtypes......Page 65
Interactions Between Afferent Nerve Subtypes Evoking Cough......Page 68
References......Page 72
Introduction......Page 80
Dorsal Respiratory Group......Page 82
Medullary Raphe Nuclei......Page 84
Nucleus Tractus Solitarii......Page 85
Cerebellum......Page 86
Cough Gating Mechanism/Process......Page 88
Laryngeal Expiration Reflex......Page 89
References......Page 92
Tachykinins and Tachykinin Receptors in the Airways......Page 96
Involvement of Tachykinins in Cough......Page 99
Tachykinin Receptor Antagonists and Cough......Page 102
Conclusion......Page 105
References......Page 106
Introduction......Page 112
Clinical Aspects of ACE Inhibitor-Induced Cough......Page 113
Enzymatic Modulation of ACE and ACE Inhibitors......Page 114
Pathogenesis of ACE Inhibitor-Induced Cough......Page 115
Clinical Management of ACE Inhibitor-Induced Cough......Page 122
Summary......Page 123
References......Page 124
Introduction......Page 136
Molecular Mechanisms Underlying the Cough Response in Primary Sensory Neurons......Page 137
Modes of Activation and/or Sensitization of TRPV1......Page 140
Pharmacological Intervention in TRPV1-Mediated Cough......Page 143
Conclusions......Page 147
References......Page 148
The Normal and Abnormal Cough Reflex......Page 156
The Enhanced Cough Reflex......Page 157
Potential Novel Classes of Antitussives (Table 1)......Page 159
Conclusion......Page 166
References......Page 167
Introduction......Page 174
Cough Production Mechanism......Page 175
Recording and Analysis of the Cough Sound......Page 176
Conclusions......Page 188
References......Page 189
Cough Inhalation Challenge......Page 192
Capsaicin Inhalation Challenge......Page 193
References......Page 203
Introduction......Page 208
Historical Aspects......Page 209
Delivery of Acid Tussives......Page 210
Methodology of Acid Inhalation Cough Challenge......Page 211
Mechanisms of Citric Acid-Induced Cough......Page 214
Animal Studies......Page 216
Human Studies......Page 217
References......Page 220
Introduction......Page 226
Physiology of Cough......Page 227
Modulation of Coughing Induced by Water Solutions......Page 236
Cough Challenges with Water Aerosols in the Clinical Setting......Page 237
Assessment of Cough......Page 239
Conclusions......Page 240
References......Page 241
Definition of Acute Cough......Page 246
Epidemiology......Page 247
Mechanisms......Page 250
Treatment......Page 256
Conclusions......Page 263
References......Page 264
Introduction......Page 268
Anatomic Diagnostic Protocol......Page 269
Initial Clinical Assessment......Page 270
References......Page 276
Gastroesophageal Reflux......Page 280
Pathogenesis of Gastroesophageal Reflux Disease......Page 281
The Role of Gastroesophageal Reflux in the Pathogenesis of Cough......Page 282
Summary......Page 292
References......Page 293
Introduction......Page 298
Gastroesophageal Reflux Disease: The Current Approach to Diagnosis and Treatment......Page 299
Treatment of Gastroesophageal Reflux in Patients with Chronic Cough......Page 304
Antireflux Surgery......Page 317
Results of Surgery for Patients with Cough......Page 319
Summary: Approach to the Management of Patients with Cough Due to Gastroesophageal Reflux......Page 323
References......Page 325
Introduction......Page 334
Cough-Variant Asthma in Adults......Page 335
Cough-Variant Asthma in Children......Page 338
Pathophysiology......Page 339
Pathology......Page 341
Neuropeptide Expression......Page 343
Natural History......Page 344
Treatment......Page 345
Relationship of Cough-Variant Asthma to Eosinophilic Bronchitis and to "Atopic Cough"......Page 346
References......Page 347
Introduction......Page 354
Clinical Features and Diagnosis......Page 355
Treatment......Page 358
Pathogenesis of Eosinophilic Bronchitis......Page 359
Natural History of Eosinophilic Bronchitis......Page 360
References......Page 362
Introduction......Page 364
Differential Diagnosis of PND......Page 365
Treatment of Cough Due to PND......Page 370
Conclusion......Page 372
References......Page 373
Introduction......Page 376
Differential Diagnosis......Page 377
Clinical Management......Page 387
References......Page 389
Introduction......Page 392
Cough Reflex Sensitivity in Normal Subjects......Page 393
The Cough Reflex and Irritant Exposure......Page 396
How Is the Cough Reflex Enhanced in Disease?......Page 397
References......Page 399
Gender Distribution in Causes of Chronic Cough......Page 404
Gender Difference in Cough Reflex Sensitivity......Page 408
Possible Mechanism of Female Preponderance in Chronic Cough......Page 411
References......Page 414
Introduction......Page 420
Assessment of Health Status......Page 421
References......Page 429
Introduction......Page 432
Major Conceptual Differences in Children and Adults with Chronic Cough......Page 433
Causes of Chronic Cough in Children......Page 434
Assessment and Management of Childhood Chronic Cough......Page 445
Investigation of Childhood Chronic Cough......Page 447
References......Page 450
Index......Page 458
Back cover......Page 466