Activation, Metabolism and Perfusion of the Heart: Simulation and experimental models

Front Matter....Pages I-XXVI
Front Matter....Pages 1-1
Use of computer simulations for combined experimental-theoretical study of anisotropic discontinuous propagation at a microscopic level in the cardiac muscle....Pages 3-27
The role of the interstitial space in electrical models of cardiac sources....Pages 29-39
Parasympathetic control of the SA node cell in rabbit heart — a model....Pages 41-59
Effects of the discrete cellular structure on electrical propagation in cardiac tissue....Pages 61-76
Electrical field model for electric interactions between myocardial cells....Pages 77-113
The role of distributed conduction velocities in simulated epicardial activation maps....Pages 115-131
Effects of anisotropy on functional reentrant circuits: preliminary results of computer simulation studies....Pages 133-150
Interaction of oscillatory currents and steady-state membrane conductance in isolated cardiac myocytes: Experimental description and preliminary modeling of syncytial effects....Pages 151-170
General discussion....Pages 171-178
Front Matter....Pages 179-179
Influence of pacing site on ventricular mechanics....Pages 181-200
Effect of alterations of the left ventricular activation sequence on left ventricular performance....Pages 201-215
Effect of the thyroid state on ventricular action potential characteristics in the mammalian heart....Pages 217-226
Mechano-electric coupling in myocardium and its possible role in ischaemic arrhythmia....Pages 227-239
Tetanization of intact hearts: a new strategy for studying the response of the contractile proteins to calcium....Pages 241-252
Modulation properties of myocardial contractile proteins....Pages 253-260
Insight into excitation-contraction coupling of heart derived from studies of the force-interval relationship....Pages 261-279
Model of Ca release mechanism from the sarcoplasmic reticulum: Ca-mediated activation, inactivation and reactivation....Pages 281-296
Front Matter....Pages 297-297
A three-dimensional constitutive law for the passive myocardium based on a microstructural approach....Pages 299-312
3-D simulation of left ventricular contraction combining myocardial mechanics and electrical activation....Pages 313-339
The mechanical effects of the pericardium on the left ventricle....Pages 341-351
Front Matter....Pages 297-297
Conversion of fiber stress to global left ventricular pump work....Pages 353-364
Front Matter....Pages 365-365
An analysis of a vascular arborization model for the microcirculation....Pages 367-372
Delineating coronary hemodynamic mechanisms by computer simulation....Pages 373-388
Distensibility of microvasculature and its consequences on coronary arterial and venous flow....Pages 389-407
Impedance to coronary flow....Pages 409-419
Intramyocardial blood volume — implications for analysis of myocardial mechanical characteristics via in vivo imaging of the heart....Pages 421-432
Effect of wall forces on coronary flow....Pages 433-440
Experimental validation studies related to clinical applications of cine computed tomography....Pages 441-449
Front Matter....Pages 451-451
Regional ventricular function in myocardial ischemia....Pages 453-462
Simulation of the mechanics of an infarcted left ventricle....Pages 463-477
Nonischemic dysfunction at the lateral margins of ischemic myocardium....Pages 479-500
Assisted circulation as a tool for the study of cardiac models and cardiac performance....Pages 501-517
Modulation of coronary autoregulatory responses....Pages 519-531
Is stunned myocardium energy deficient?....Pages 533-548
Concentric left ventricular hypertrophy: a simulation study of mechanics related to transmural oxygen demand and perfusion....Pages 549-566
Coronary reserves in myocardial hypertrophy....Pages 567-582
Front Matter....Pages 583-583
Making mathematical descriptions of metabolic reaction networks manageable....Pages 585-620
Integrated phenomenology of transport, permeation, and metabolic reactions in the heart....Pages 621-642
Transport between myocardial capillaries and cardiac lymphatics....Pages 643-663
Disturbances in myocardial lipid homeostasis during ischemia and reperfusion....Pages 665-682
Front Matter....Pages 583-583
Heat transfer and temperature profiles during ischemia and infarction in the left ventricular wall....Pages 683-698
Front Matter....Pages 699-699
Long-term assessment and management of chronic cardiac failure....Pages 701-705
Acute and chronic cardiac failure: the oxygen transport system gone awry....Pages 707-717
Front Matter....Pages 719-719
Interactions: mechanics, metabolism and perfusion....Pages 721-722
Relating models to experiments....Pages 723-726
Back Matter....Pages 727-737