35th Hemophilia Symposium Hamburg 2004: Epidemiology;Risk of Infections and Inhibitors in Hemophilia; Chronic lic Synovitis and Long-term Results of Orthopedic ... Hemostaseology;Free Lectures

Front Matter....Pages 1-1
HIV Infection and Causes of Death in Patients with Hemophilia in Germany (Year 2003/2004 Survey)....Pages 3-12
Hemophilia Registry of the Medical Committee of the Swiss Hemophilia Association — Update and Annual Survey 2004....Pages 13-18
Front Matter....Pages 19-19
Update on the Safety of Clotting Factors, Mainly Regarding the Risk of Transmission of vCJD (Variant Creutzfeldt Jakob Disease)....Pages 21-28
nvCJD and Blood Products in the UK....Pages 29-32
Mutation Type Dependent Inhibitor Risk — a Single Center Study on 432 Patients with Severe Hemophilia A....Pages 33-33
Inhibitor Incidence in Previously Untreated Patients (PUPs) with Hemophilia A and B. A Prospective Multi-Center Study of the Pediatric Committee of the German, Swiss and Austrian Society for Thrombosis and Hemostasis Research (GTH)....Pages 34-37
ADVATE Inhibitor Risk Profile: 18 Months post-Licensure....Pages 38-41
EACH-Registry: An European Registry for Acquired Hemophilia....Pages 42-43
Elective Orthopedic Surgery for Hemophilia Patients with Inhibitors....Pages 44-46
Front Matter....Pages 47-47
Results after Total Knee and Hip Replacement in Patients with Hemophilia A — A Single Center Experience....Pages 49-51
Motion Analysis Epidemiology in Hemophilic Children....Pages 52-56
Radiosynoviorthesis in Hemophilic Arthropathy — A Single Center Experience....Pages 57-58
Front Matter....Pages 59-59
Individual Therapy of Hemophilia — New Laboratory Methods Considering Platelets....Pages 61-65
Epitope Mapping during FVIII Inhibitor Elimination with Rituximab Reveals Conformational Epitopes on FVIII and Identifies Small Molecules Blocking Inhibitor and Targeting B Cells....Pages 66-80
Lack of Factor VIII Expression Represents a Novel Mechanism Leading to Hemophilia A....Pages 81-84
Front Matter....Pages 85-85
Effects of the Factor V G1691 A Mutation and the Factor II G20210A Variant on the Clinical Expression of Severe Hemophilia A (< 2%) in Children — Results of a Multicenter Study....Pages 87-94
Continuous Infusion of Factor Concentrates in Children with Hemophilia A in Comparison to Bolus Injections....Pages 95-101
Decreased Clotting Factor Activity (VIII, IX, XI, and XII) due to Inhibitors with Lupus-like Activity in Childhood....Pages 102-106
Front Matter....Pages 107-107
Effect of Activated Recombinant Coagulation Factor VII on the Function of Glycoprotein IIb/IIIa-Inhibited Platelets in Vitro....Pages 109-119
Mutation Analysis in Hereditary Angioedema Identifies Patients at Risk for Developing Acute and Life Threatening Edema....Pages 120-122
Front Matter....Pages 107-107
Recurrent Mutation in ADAMTS13 Gene as a Cause of a Hereditary Thrombotic Thrombocytopenic Purpura in the Czech Republic....Pages 123-125
Clinical Manifestations of Patients with Dysfibrinogenemia....Pages 126-129
Case Report of a FXIII Inhibitor in a 77-year-old Patient....Pages 130-132
Front Matter....Pages 133-133
The ABC’s of Hemophilia....Pages 135-135
The Long Journey to Being Diagnosed as a Carrier of Hemophilia A — A Woman with Abnormally Prolonged Bleeding after Myocardial Infarction....Pages 136-137
Clinical Investigation of Orthopedic Outcome in Patients with Severe Hemophilia — Advantage of an Early Prophylactic Treatment?....Pages 138-141
The Relevance of Thrombophilic Risk Factors on Bleeding Tendency in Hemophilia A Patients....Pages 142-143
Magnetic Field Therapy in Patients with Severe Hemophilia — Motion Analysis and Quality Control....Pages 144-149
The Clinical Course of two Patients Receiving High Dose Factor VIII — Replacement Therapy....Pages 150-152
Determination of the Factor VIII Plasma Activity of Hemophilia A Patients Treated with a New Recombinant Factor VIII Concentrate....Pages 153-156
Socio-Economic Aspects of Hemophilia Treatment in Romania....Pages 157-164
Immunosuppressive Treatment in Acquired von-Willebrand’s Syndrome....Pages 165-167
HCV-Infection in HIV-Infected and Non-Infected People with Hemophilia — A Retrospective Study: Medical Aspects....Pages 168-172
HCV-Infection in HIV-Infected and Non-Infected People with Hemophilia — A Retrospective Study: Psychosocial Aspects....Pages 173-178
Testing Factor VIII Activity by Using the Chromogenic Assay in Carriers of Hemophilia A....Pages 179-182
Hip Replacement in Hemophilic Patients — A 30 Years Single Center Experience....Pages 183-184
Successful Therapy with anti CD20 Monoclonal Antibody Rituximab in Patients with Acquired Hemophilia against Factor VIII....Pages 187-189
Unusual Prolonged Course of an Immune Tolerance Therapy (ITT) in a Patient with Severe Hemophilia A and a High-Titer Inhibitor Development....Pages 190-193
Successful Major Surgery with Minimal Dosage of rFVIIa in a Hemophilia A Patient with High Level of Alloantibodies to Factor VIII....Pages 194-197
Inhibitor Development after Continuous Infusion of Factor VIII: A Retrospective Study in Germany....Pages 198-200
Front Matter....Pages 133-133
Inhibitors in PTP’S: A Retrospective Study in Germany....Pages 201-204
Elective Orthopedic Surgery in Inhibitor Patients — the Frankfurt Concept....Pages 205-205
The Frequency of Venous Thromboembolism in Women with FV Leiden in Association with Pregnancy and Puerperium....Pages 209-212
Spectrum of Molecular Defects and Mutation Detection Date in Patients with Severe Hemophilia A....Pages 215-218
Hemophilia Patients and Prothrombotic Gene Mutation....Pages 219-220
γA1a82Gly Represents a Common Fibrinogen Chain Variant in Caucasians....Pages 221-225
A Novel Mutation (Asp36Tyr) in the Vitamin K Epoxide Reductase Complex Subunit 1 Gene (VKORC1) Causes Increased Phenprocoumon Requirement....Pages 226-229
Denaturing High Performance Liquid Chromatography Represents an Efficient Technique for Detection of Heterozygous Large Deletions in Antithrombin Gene....Pages 230-232
Recurrent Coronary Stent Thrombosis in a Patient with Combined Aspirin and Clopidogrel Resistance....Pages 235-238
Coagulation Factor XIII Mutation Profile: Update 2004....Pages 239-241
Site-Directed Mutagenesis of VKORC1, the Target Protein of Coumarin-Type Anticoagulants....Pages 242-244
Treatment of Dilution Coagulopathy by Fibrinogen and Platelet Concentrates....Pages 245-246
Pathogenesis of Hepatic Veno-Occlusive Disease in Patients Undergoing Hematopoietic Stem Cell Transplantation....Pages 247-258