30th Hemophilia Symposium Hamburg 1999

Front Matter....Pages I-XXXIV
Front Matter....Pages 1-1
Causes of Death and AIDS-Related Disease in Hemophilia Patients in Germany (Inquiries 1999)....Pages 3-10
Front Matter....Pages 11-11
Genotype-Phenotype Correlation in Hemophilia A....Pages 13-21
Front Matter....Pages 23-23
Current Therapy of Hepatitis C Virus Infection....Pages 25-31
Interferon Alpha-2a Treatment in Patients with Hepatitis C and Bleeding Disorders....Pages 32-34
Report on Experience in the Treatment of Hepatitis C in HIV-Coinfected Hemophiliacs....Pages 35-41
Front Matter....Pages 43-43
A New Therapeutic Option for Inhibitor Elimination in Patients with Acquired Hemophilia....Pages 45-52
Front Matter....Pages 53-53
Long-Term Results After Total Knee and Total Hip Replacement in Hemophilic Arthropathy....Pages 55-61
Total Knee Prosthesis in Hemophiliacs with Multilocular Hemophilic Arthropathy — The Zurich Experience....Pages 62-64
Corrective Osteotomy of the Lower Extremity in Hemophilic Arthropathy of the Knee and Hip Joint....Pages 65-70
Front Matter....Pages 71-71
Anticoagulant Action of Activated Protein C is Diminished by Alpha 2 -Macroglobulin in Newborn Plasma....Pages 73-85
Functional Consequences of Differences in Carbohydrate Sequences of Fetal and Adult Plasminogen and Fibrinogen....Pages 86-101
Hereditary Thrombophilic Risk Profiles in Children with Spontaneous Venous Thromboembolism....Pages 102-109
Inhibitor Development in Previously Untreated Patients with Hemophilia A and B: A Prospective 23-Year Follow-Up....Pages 110-113
HIT Type II without Thrombocytopenia in a 15-Year-Old Boy with Protein S Deficiency and Recurrent Deep Vein Thrombosis....Pages 114-116
Front Matter....Pages 117-117
Modified Bonn-Malmö Protocol....Pages 119-125
A Novel Type of Mutation at the Propeptide Cleavage Site (Ala+1Thr) Causing Symptomatic Protein C Type II Deficiency....Pages 126-131
Lithuanian Hemophilia A and B Register Comprising Phenotypic and Genotypic Data....Pages 132-143
Greifswald Hemophilia B Study....Pages 144-153
Successful Treatment of Patients with von Willebrand Disease Using a High-Purity Double Virus Inactivated FVIII/vWF Concentrate (IMMUNATE)....Pages 154-160
Front Matter....Pages 161-161
Industry Sponsoring and Acceptance of Benefit by Hospital Officials: Opportunities and Limits of Third-Party Funding....Pages 163-175
Front Matter....Pages 177-177
Experience with Recombinant Factor IX (Benefix) in Pediatrics....Pages 179-181
Articular Cartilage Is More Susceptible to Blood-Induced Damage in Young Than in Old Age....Pages 182-186
Chronic Liver Disease in Hemophilia Patients....Pages 187-190
Human Immunodeficiency Virus-Negative ››High-Risk Patients‹‹ with Hemophilia or Severe von Willebrand Disease Type 3: Coincidence or Genetics?....Pages 191-193
Quality Management and Economic Aspects in Hemotherapy in the Federal Republic of Germany: Description of a Retrospective Cross-Sectional Multicenter Trial....Pages 194-196
How Hemophiliacs View the Services Offered by ››Bluter Betreuung Bayern e.V.‹‹ Results of a Survey Carried Out for the Association’s Tenth Anniversary....Pages 197-198
Alpha Tocopherol — A Medication with Few Side Effects for Treating Pain in Patients with Hemarthrosis....Pages 199-201
Neurosensorial Sequelae in Hemophilia....Pages 202-206
Front Matter....Pages 207-207
Effect of Vitamin Supplementation in Venous Thrombosis Patients with Hyperhomocysteinemia....Pages 209-213
Therapy and Prophylaxis of the Thromboembolic Syndrome in Pregnancy and Post Delivery....Pages 214-216
Is Factor V Leiden Associated with an Increased Risk for Fetal Loss?....Pages 217-221
Front Matter....Pages 223-223
Congenital Deficiency of Vitamin K Dependent Coagulation Factors in Two Families: Evidence for a Defective Vitamin K-Epoxide-Reductase Complex....Pages 225-234
Twenty-Two Novel Mutations of Factor VII Gene in Factor VII Deficiency....Pages 235-239
Prevalence of Common Mutations and Polymorphisms of the Genes of FII, FV, FVII, FXII, FXIII, MTHFR and ACE — Identified As Risk Factors for Venous and Arterial Thrombosis — in Germany and Different Ethnic Groups (Indians, Blacks) of Costa Rica....Pages 240-260
Factor V Variants — FV Leiden, FV R2 Polymorphism (ex 13), FV Ddel Polymorphism (int 16) - Risk Factors for Venous Thrombosis? Results of a Pilot Study....Pages 261-265
Relation Between Prothrombin Mutation 20210 G→A, Prothrombin Time, Factor V Leiden, and Prothrombin Level....Pages 266-269
Localization and Characterization of Mutations Within the Factor VIII Gene in a Cohort of 212 Patients with Hemophilia A....Pages 270-272
Genomic Diagnosis of Hemophilia A in Hungarian Patients....Pages 273-276
Indirect Genomic Diagnosis of Hungarian Hemophilia B Patients....Pages 277-279
Front Matter....Pages 281-281
Relation of Cardiovascular Fitness, Hemostatic and Metabolic Risk Factors for Coronary Heart Disease in Obese Children and Adolescents....Pages 283-291
Front Matter....Pages 281-281
Inverse Correlation Between Thyroid Function and Hemostatic Risk Factors for Coronary Heart Disease in Obese Children and Adolescents....Pages 292-298
Heparin-Induced Thrombocytopenia Type II in Three Children and Anticoagulant Therapy with Org 10172 (Orgaran)....Pages 299-302
Heparin Concentration, Activated Clotting Time, and Markers of Coagulation Activation During Pediatric Heart Catheterization....Pages 303-306
Therapeutic Options in Immune Thrombocytopenic Purpura in Childhood....Pages 307-312
Camps for Children and Young Adults with Hemophilia in Germany, Austria, and Switzerland....Pages 313-316
Clinical Experience with the PFA-100 System in Children and Adolescents....Pages 317-320
Endothelial Activation Markers in Health and Disease — Big Endothelin-1 and Endothelin-1 in Children....Pages 321-330
Front Matter....Pages 331-331
Dramatic Intra-Abdominal Bleeding — First Symptom of Hemophilia B in a Neonate....Pages 333-335
Postoperative Bleeding in a Sufficiently Substituted Patient with Severe Hemophilia A: Successful Therapy with Administration of Recombinant Factor VIIa....Pages 336-341
Continuous Infusion of Recombinant FIX (BeneFIX) During Herniotomy in an Infant....Pages 342-344
Clinical Course of Intramuscular Bleeds in a Patient with Factor XIII Deficiency....Pages 345-346
Immunthrombocytopenia and Lupus Antibodies in a Patient with Hemophilia A....Pages 347-349
Cerebral Sinus Thrombosis after Asparaginase Therapy....Pages 350-353
Severe Neonatal Thrombosis in a Patient with Factor V Q:506 Mutation and the G20210A Prothrombin Mutation....Pages 354-357
Elevated Lp(a) Level and Heterozygous Factor V Mutation FV 1691 AG in a 26-Year-0ld Female with Ischemic Colitis....Pages 358-360
Acquired Hemophilia in Women Postpartum....Pages 361-362
Front Matter....Pages 363-363
Modulation of Antigens of Neutrophil Granulocytes by Extracorporal Apheresis....Pages 365-368
Glycoprotein IIb/IIIa Receptor Antagonist c7E3 Fab and Anticoagulants Show an Additive Effect on Thrombin-Induced Platelet Aggregation after High Coagulant Challenge in Vitro....Pages 369-377
Between-Drug Comparison of the Effect of Ticlopidine and Acetylsalicylic Acid on Platelets in an In Vitro Circulation Model....Pages 378-379
Rotablation Leads to Significant Platelet Activation: A Flow Cytometric Assessment....Pages 380-381
Front Matter....Pages 363-363
Flow Cytometric Comparison of Platelet Activation During PTCA, Stent Implantation, and Rotablation....Pages 382-383
Analysis of Hemostatic Capacity before and after Extracorporal Platelet-Pheresis by the PFA-100 Test System....Pages 384-387
Heparin Coating of Coronary Stents Increases Time Until Stent Occlusion Due to Delayed Platelet Activation in an In Vitro Circulating Model....Pages 388-389
High-Speed Detection of Human Progenitor Cells (HPC) to Support the Timing of Aphereses....Pages 390-393
Semi-Automated Flow Cytometry Can Help in Timing the Onset of a Stem-Cell Leukapheresis....Pages 394-398
Front Matter....Pages 399-399
Current Topics of Official Batch Release: Determination of FXIII Activity in Fibrin Glues and FXIII Concentrates and Measurement of Heparin/AT Complexes in FVIII Products....Pages 401-407
Comparison of BVDV and SFV Used as Models for Hepatitis C Virus in Virus Validation Studies....Pages 408-416
Preoperative Coagulation Screening in Children Focused on PTT Elevation....Pages 417-419
Resonance Thrombographic Analysis of Coagulation Status after Transfusion of Platelet Concentrates with Different Storage Times....Pages 420-421
Back Matter....Pages 423-427