2020 Nelson’s Pediatric Antimicrobial Therapy

1. Choosing Among Antibiotics Within a Class: Beta-lactams and Beta-lactamase 
Inhibitors, Macrolides, Aminoglycosides, and Fluoroquinolones......Page 13
2. Choosing Among Antifungal Agents: Polyenes, Azoles, and Echinocandins......Page 21
3. How Antibiotic Dosages Are Determined Using Susceptibility Data, Pharmacodynamics, and Treatment Outcomes......Page 31
4. Approach to Antibiotic Therapy of Drug-Resistant Gram-negative Bacilli 
and Methicillin-Resistant Staphylococcus aureus......Page 35
5. Antimicrobial Therapy for Newborns......Page 43
A. Recommended Therapy for Selected Newborn Conditions......Page 45
B. Antimicrobial Dosages for Neonates......Page 67
C. Aminoglycosides......Page 71
E. Use of Antimicrobials During Pregnancy or Breastfeeding......Page 72
6. Antimicrobial Therapy According to Clinical Syndromes......Page 75
A. Skin and Soft Tissue Infections......Page 78
B. Skeletal Infections......Page 84
C. Eye Infections......Page 87
D. Ear and Sinus Infections......Page 91
E. Oropharyngeal Infections......Page 94
F. Lower Respiratory Tract Infections......Page 97
G. Cardiovascular Infections......Page 110
H. Gastrointestinal Infections......Page 117
I. Genital and Sexually Transmitted Infections......Page 124
J. Central Nervous System Infections......Page 128
K. Urinary Tract Infections......Page 133
L. Miscellaneous Systemic Infections......Page 135
7. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens......Page 143
A. Common Bacterial Pathogens and Usual Pattern of Susceptibility to 
Antibiotics (Gram Positive)......Page 144
B. Common Bacterial Pathogens and Usual Pattern of Susceptibility to

Antibiotics (Gram Negative)......Page 146
C. Common Bacterial Pathogens and Usual Pattern of Susceptibility to

Antibiotics (Anaerobes)......Page 148
D. Preferred Therapy for Specific Bacterial and Mycobacterial Pathogens......Page 150
8. Preferred Therapy for Specific Fungal Pathogens......Page 171
A. Overview of More Common Fungal Pathogens and Their Usual Pattern

of Antifungal Susceptibilities......Page 172
B. Systemic Infections......Page 174
C. Localized Mucocutaneous Infections......Page 188
9. Preferred Therapy for Specific Viral Pathogens......Page 189
B. Overview of Hepatitis B or C Viral Pathogens and Usual Pattern of

Susceptibility to Antivirals......Page 190
C. Preferred Therapy for Specific Viral Pathogens......Page 192
10. Preferred Therapy for Specific Parasitic Pathogens......Page 207
A. Selected Common Pathogenic Parasites and Suggested 
Agents for Treatment......Page 208
B. Preferred Therapy for Specific Parasitic Pathogens......Page 210
11. Alphabetic Listing of Antimicrobials......Page 231
A. Systemic Antimicrobials With Dosage Forms and Usual Dosages......Page 233
B. Topical Antimicrobials (Skin, Eye, Ear, Mucosa)......Page 256
12. Antibiotic Therapy for Children Who Are Obese......Page 263
13. Sequential Parenteral-Oral Antibiotic Therapy (Oral Step-down Therapy)

for Serious Infections......Page 267
14. Antimicrobial Prophylaxis/Prevention of Symptomatic Infection......Page 269
A. Postexposure Antimicrobial Prophylaxis to Prevent Infection......Page 271
B. Long-term Antimicrobial Prophylaxis to Prevent Symptomatic New Infection......Page 277
C. Prophylaxis of Symptomatic Disease in Children Who Have Asymptomatic

Infection/Latent Infection......Page 278
D. Surgical/Procedure Prophylaxis......Page 281
Appendix: Nomogram for Determining Body Surface Area......Page 287
References......Page 289
Index......Page 313